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Investigation of protein-protein interactions in cancer targeted therapy using nanorobots
Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超); Dong ZL(董再励); Xiao XB(肖秀斌); Zhang WJ(张伟京)
Department机器人学研究室
Source PublicationSelected Topics in Micro/Nano-robotics for Biomedical Applications
ContributorYi Guo
PublisherSpringer-Verlag
Publication PlaceBerlin
2013
ISBN978-1-4419-8410-4
Pages125-158
Indexed ByEI
EI Accession number20172603851767
AbstractThis chapter describes the applications of nanorobots in investigating the mechanisms of rituximab’s different efficacies in the targeted therapy of B-cell lymphomas at the individual cellular/molecular level. The chapter begins with an introduction to the new challenges in the field of cancer targeted therapy, taking rituximab targeted therapy in B-cell lymphoma for example. The following section presents a detailed description of the principles and methods of single-molecule techniques based on nanorobots. Next, it presents the microfabricated pillar-based cell immobilization method and discusses how to obtain the topography of individual living mammalian suspension cells based on this immobilization method. Next, it presents how to use nanorobot indentation experiments to measure the mechanical properties of individual cells. Next, the processes of using nanorobots to measure the individual molecular binding forces and three-dimensionally visualize the distribution of CD20 proteins on the lymphoma cell surface with the probe functionalization technology are detailed. The remainder of the chapter presents the specific binding force measurements on different lymphoma patients’ cells and discusses its relation to rituximab’s variable efficacies. The intent of this chapter is to provide the practical knowledge to begin the investigations on individual cells and molecules with nanorobots.
Language英语
Contribution Rank1
Document Type专著章节/文集论文
Identifierhttp://ir.sia.cn/handle/173321/10252
Collection机器人学研究室
Corresponding AuthorLiu LQ(刘连庆); Xi N(席宁)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.Department of Electrical and Computer Engineering, Michigan State University, East Lansing, United States
3.Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing, China
Recommended Citation
GB/T 7714
Li M,Liu LQ,Xi N,et al. Investigation of protein-protein interactions in cancer targeted therapy using nanorobots. Selected Topics in Micro/Nano-robotics for Biomedical Applications. Berlin:Springer-Verlag,2013:125-158.
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