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Investigation of protein-protein interactions in cancer targeted therapy using nanorobots
Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超); Dong ZL(董再励); Xiao XB(肖秀斌); Zhang WJ(张伟京)
作者部门机器人学研究室
专著(文集)名Selected Topics in Micro/Nano-robotics for Biomedical Applications
编著者Yi Guo
出版者Springer-Verlag
出版地Berlin
2013
ISBN号978-1-4419-8410-4
出处页码125-158
收录类别EI
EI收录号20172603851767
摘要This chapter describes the applications of nanorobots in investigating the mechanisms of rituximab’s different efficacies in the targeted therapy of B-cell lymphomas at the individual cellular/molecular level. The chapter begins with an introduction to the new challenges in the field of cancer targeted therapy, taking rituximab targeted therapy in B-cell lymphoma for example. The following section presents a detailed description of the principles and methods of single-molecule techniques based on nanorobots. Next, it presents the microfabricated pillar-based cell immobilization method and discusses how to obtain the topography of individual living mammalian suspension cells based on this immobilization method. Next, it presents how to use nanorobot indentation experiments to measure the mechanical properties of individual cells. Next, the processes of using nanorobots to measure the individual molecular binding forces and three-dimensionally visualize the distribution of CD20 proteins on the lymphoma cell surface with the probe functionalization technology are detailed. The remainder of the chapter presents the specific binding force measurements on different lymphoma patients’ cells and discusses its relation to rituximab’s variable efficacies. The intent of this chapter is to provide the practical knowledge to begin the investigations on individual cells and molecules with nanorobots.
语种英语
产权排序1
文献类型专著章节/文集论文
条目标识符http://ir.sia.cn/handle/173321/10252
专题机器人学研究室
通讯作者Liu LQ(刘连庆); Xi N(席宁)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.Department of Electrical and Computer Engineering, Michigan State University, East Lansing, United States
3.Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing, China
推荐引用方式
GB/T 7714
Li M,Liu LQ,Xi N,et al. Investigation of protein-protein interactions in cancer targeted therapy using nanorobots. Selected Topics in Micro/Nano-robotics for Biomedical Applications. Berlin:Springer-Verlag,2013:125-158.
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