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Atomic force microscopy imaging and mechanical properties measurement of red blood cells and aggressive cancer cells
Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超); Dong ZL(董再励); Xiao XB(肖秀斌); Zhang WJ(张伟京)
作者部门机器人学研究室
关键词Atomic Force Microscopy Red Blood Cell Cancer Cell Mechanical Properties Young's Modulus
发表期刊SCIENCE CHINA: Life Sciences
ISSN1674-7305
2012
卷号55期号:11页码:968-973
收录类别SCI
WOS记录号WOS:000311398500005
产权排序1
摘要

Mechanical properties play an important role in regulating cellular activities and are critical for unlocking the mysteries of life. Atomic force microscopy (AFM) enables researchers to measure mechanical properties of single living cells under physiological conditions. Here, AFM was used to investigate the topography and mechanical properties of red blood cells (RBCs) and three types of aggressive cancer cells (Burkitt’s lymphoma Raji, cutaneous lymphoma Hut, and chronic myeloid leukemia K562). The surface topography of the RBCs and the three cancer cells was mapped with a conventional AFM probe, while mechanical properties were investigated with a micro-sphere glued onto a tip-less cantilever. The diameters of RBCs are significantly smaller than those of the cancer cells, and mechanical measurements indicated that Young’s modulus of RBCs is smaller than those of the cancer cells. Aggressive cancer cells have a lower Young’s modulus than that of indolent cancer cells, which may improve our understanding of metastasis.

语种英语
WOS标题词Science & Technology ; Life Sciences & Biomedicine
WOS类目Biology
关键词[WOS]Lymphoma ; Biomechanics ; Cytoskeleton ; Elasticity ; Adhesion
WOS研究方向Life Sciences & Biomedicine - Other Topics
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/10360
专题机器人学研究室
通讯作者Liu LQ(刘连庆); Xi N(席宁); Zhang WJ(张伟京)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.University of Chinese Academy of Sciences, Beijing, China
3.Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China
4.Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing, China5.State Key Laboratory of Drug Research, Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina
推荐引用方式
GB/T 7714
Li M,Liu LQ,Xi N,et al. Atomic force microscopy imaging and mechanical properties measurement of red blood cells and aggressive cancer cells[J]. SCIENCE CHINA: Life Sciences,2012,55(11):968-973.
APA Li M.,Liu LQ.,Xi N.,Wang YC.,Dong ZL.,...&Zhang WJ.(2012).Atomic force microscopy imaging and mechanical properties measurement of red blood cells and aggressive cancer cells.SCIENCE CHINA: Life Sciences,55(11),968-973.
MLA Li M,et al."Atomic force microscopy imaging and mechanical properties measurement of red blood cells and aggressive cancer cells".SCIENCE CHINA: Life Sciences 55.11(2012):968-973.
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