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题名: Atomic force microscopy imaging and mechanical properties measurement of red blood cells and aggressive cancer cells
作者: Li M(李密) ; Liu LQ(刘连庆) ; Xi N(席宁) ; Wang YC(王越超) ; Dong ZL(董再励) ; Xiao XB(肖秀斌) ; Zhang WJ(张伟京)
作者部门: 机器人学研究室
关键词: atomic force microscopy ; red blood cell ; cancer cell ; mechanical properties ; Young's modulus
刊名: SCIENCE CHINA: Life Sciences
ISSN号: 1006-9305
出版日期: 2012
卷号: 55, 期号:11, 页码:968-973
收录类别: SCI
产权排序: 1
摘要: Mechanical properties play an important role in regulating cellular activities and are critical for unlocking the mysteries of life. Atomic force microscopy (AFM) enables researchers to measure mechanical properties of single living cells under physiological conditions. Here, AFM was used to investigate the topography and mechanical properties of red blood cells (RBCs) and three types of aggressive cancer cells (Burkitt’s lymphoma Raji, cutaneous lymphoma Hut, and chronic myeloid leukemia K562). The surface topography of the RBCs and the three cancer cells was mapped with a conventional AFM probe, while mechanical properties were investigated with a micro-sphere glued onto a tip-less cantilever. The diameters of RBCs are significantly smaller than those of the cancer cells, and mechanical measurements indicated that Young’s modulus of RBCs is smaller than those of the cancer cells. Aggressive cancer cells have a lower Young’s modulus than that of indolent cancer cells, which may improve our understanding of metastasis.
WOS记录号: WOS:000311398500005
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Biology
关键词[WOS]: LYMPHOMA ; BIOMECHANICS ; CYTOSKELETON ; ELASTICITY ; ADHESION
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
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内容类型: 期刊论文
URI标识: http://ir.sia.cn/handle/173321/10360
Appears in Collections:机器人学研究室_期刊论文

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