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题名: Investigating the morphology and mechanical properties of blastomeres with atomic force microscopy
作者: Li M(李密) ; Zhang CL(张常麟) ; Wang, Liu ; Liu LQ(刘连庆) ; Xi N(席宁) ; Wang YC(王越超) ; Dong ZL(董再励)
作者部门: 机器人学研究室
关键词: Atomic force microscopy ; Cells ; Cytology ; Elastic moduli ; Morphology
刊名: Surface and Interface Analysis
ISSN号: 0142-2421
出版日期: 2013
卷号: 45, 期号:8, 页码:1193-1196
收录类别: SCI ; EI
产权排序: 1
摘要: Atomic force microscopy (AFM) was used to directly investigate the morphology and mechanical properties of blastomeres during the embryo development. With AFM imaging, the surface topography of blastomeres from two-cell, four-cell, and eight-cell stages was visualized, and the AFM images clearly revealed the blastomere's morphological changes during the different embryo developmental stages. The section measurements of the AFM topography images of the blastomeres showed that the axis of the embryos nearly kept constant during the two-cell, four-cell, and eight-cell stages. With AFM indenting, the mechanical properties of living blastomeres from several embryos were measured quantitatively under physiological conditions. The results of mechanical properties measurements indicated that the Young's modulus of the two blastomeres from two-cell embryo was different from each other, and the four blastomeres from the four-cell embryo also had variable Young's modulus. Besides, the blastomeres from two-cell embryos were significantly harder than blastomeres from four-cell embryos. These results can improve our understanding of the embryo development from the view of cell mechanics. © 2013 John Wiley & Sons, Ltd.
语种: 英语
WOS记录号: WOS:000321445800001
WOS标题词: Science & Technology ; Physical Sciences
类目[WOS]: Chemistry, Physical
关键词[WOS]: CELL MECHANICS ; CANCER-CELLS ; MOUSE ; BLASTOCYST
研究领域[WOS]: Chemistry
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内容类型: 期刊论文
URI标识: http://ir.sia.cn/handle/173321/10632
Appears in Collections:机器人学研究室_期刊论文

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