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Investigating the morphology and mechanical properties of blastomeres with atomic force microscopy
Li M(李密); Zhang CL(张常麟); Wang, Liu; Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超); Dong ZL(董再励)
作者部门机器人学研究室
关键词Atomic Force Microscopy Cells Cytology Elastic Moduli Morphology
发表期刊Surface and Interface Analysis
ISSN0142-2421
2013
卷号45期号:8页码:1193-1196
收录类别SCI ; EI
EI收录号20132916516182
WOS记录号WOS:000321445800001
产权排序1
摘要Atomic force microscopy (AFM) was used to directly investigate the morphology and mechanical properties of blastomeres during the embryo development. With AFM imaging, the surface topography of blastomeres from two-cell, four-cell, and eight-cell stages was visualized, and the AFM images clearly revealed the blastomere's morphological changes during the different embryo developmental stages. The section measurements of the AFM topography images of the blastomeres showed that the axis of the embryos nearly kept constant during the two-cell, four-cell, and eight-cell stages. With AFM indenting, the mechanical properties of living blastomeres from several embryos were measured quantitatively under physiological conditions. The results of mechanical properties measurements indicated that the Young's modulus of the two blastomeres from two-cell embryo was different from each other, and the four blastomeres from the four-cell embryo also had variable Young's modulus. Besides, the blastomeres from two-cell embryos were significantly harder than blastomeres from four-cell embryos. These results can improve our understanding of the embryo development from the view of cell mechanics. © 2013 John Wiley & Sons, Ltd.
语种英语
WOS标题词Science & Technology ; Physical Sciences
WOS类目Chemistry, Physical
关键词[WOS]CELL MECHANICS ; CANCER-CELLS ; MOUSE ; BLASTOCYST
WOS研究方向Chemistry
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文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/10632
专题机器人学研究室
通讯作者Liu LQ(刘连庆); Xi N(席宁)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.University of Chinese Academy of Sciences, Beijing 100049, China
3.State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
4.Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong
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GB/T 7714
Li M,Zhang CL,Wang, Liu,et al. Investigating the morphology and mechanical properties of blastomeres with atomic force microscopy[J]. Surface and Interface Analysis,2013,45(8):1193-1196.
APA Li M.,Zhang CL.,Wang, Liu.,Liu LQ.,Xi N.,...&Dong ZL.(2013).Investigating the morphology and mechanical properties of blastomeres with atomic force microscopy.Surface and Interface Analysis,45(8),1193-1196.
MLA Li M,et al."Investigating the morphology and mechanical properties of blastomeres with atomic force microscopy".Surface and Interface Analysis 45.8(2013):1193-1196.
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