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Self-Rotation of Cells in an Irrotational AC E-Field in an Opto-Electrokinetics Chip
Chau, LH; Liang WF(梁文峰); Cheung, FWK; Liu, WK; Li WJ(李文荣); Chen, SC; Lee, GB
Department机器人学研究室
Source PublicationPLOS ONE
ISSN1932-6203
2013
Volume8Issue:1Pages:1-8
Indexed BySCI
WOS IDWOS:000313429800009
Contribution Rank2
KeywordElectric-field Dielectrophoresis Manipulation Separation
AbstractThe use of optical dielectrophoresis (ODEP) to manipulate microparticles and biological cells has become increasingly popular due to its tremendous flexibility in providing reconfigurable electrode patterns and flow channels. ODEP enables the parallel and free manipulation of small particles on a photoconductive surface on which light is projected, thus eliminating the need for complex electrode design and fabrication processes. In this paper, we demonstrate that mouse cells comprising melan-a cells, RAW 267.4 macrophage cells, peripheral white blood cells and lymphocytes, can be manipulated in an opto-electrokinetics (OEK) device with appropriate DEP parameters. Our OEK device generates a non-rotating electric field and exerts a localized DEP force on optical electrodes. Hitherto, we are the first group to report that among all the cells investigated, melan-a cells, lymphocytes and white blood cells were found to undergo self-rotation in the device in the presence of a DEP force. The rotational speed of the cells depended on the voltage and frequency applied and the cells' distance from the optical center. We discuss a possible mechanism for explaining this new observation of induced self-rotation based on the physical properties of cells. We believe that this rotation phenomenon can be used to identify cell type and to elucidate the dielectric and physical properties of cells.
Language英语
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS KeywordELECTRIC-FIELD ; DIELECTROPHORESIS ; MANIPULATION ; SEPARATION
WOS Research AreaScience & Technology - Other Topics
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Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/10636
Collection机器人学研究室
Corresponding AuthorLiu, WK; Li WJ(李文荣)
Affiliation1.Centre for Micro and Nano Systems, The Chinese University of Hong Kong, Hong Kong
2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
3.School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
4.Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong
5.Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan
Recommended Citation
GB/T 7714
Chau, LH,Liang WF,Cheung, FWK,et al. Self-Rotation of Cells in an Irrotational AC E-Field in an Opto-Electrokinetics Chip[J]. PLOS ONE,2013,8(1):1-8.
APA Chau, LH.,Liang WF.,Cheung, FWK.,Liu, WK.,Li WJ.,...&Lee, GB.(2013).Self-Rotation of Cells in an Irrotational AC E-Field in an Opto-Electrokinetics Chip.PLOS ONE,8(1),1-8.
MLA Chau, LH,et al."Self-Rotation of Cells in an Irrotational AC E-Field in an Opto-Electrokinetics Chip".PLOS ONE 8.1(2013):1-8.
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