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Dynamic separation of b-lymphoma cells from red blood cells using optically-induced electrokinetics
Liang WF(梁文峰); Liu B(刘斌); Liu LQ(刘连庆); Dong ZL(董再励); Lee, Gwo-Bin; Li WJ(李文荣); Zhang WJ(张伟京)
Department机器人学研究室
Conference Name8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
Conference DateApril 7-10, 2013
Conference PlaceSuzhou, China
Author of SourceInstitute of Electrical and Electronics Engineers (IEEE); IEEE Nanotechnology Council (NTC); Peking University; Soochow University; Chinese Academy of Sciences
Source Publication8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
PublisherIEEE Computer Society
Publication PlaceWashington, United States
2013
Pages1253-1256
Indexed ByEI ; CPCI(ISTP)
EI Accession number20133616690605
WOS IDWOS:000327183000269
Contribution Rank1
ISBN978-1-4673-6352-5
KeywordBioassay Biochips Blood Electrodes Electrodynamics Electrohydrodynamics Electromagnetic Fields Electroosmosis Electrophoresis
Abstract

This study reports an approach to dynamically separate cultured human B-lymphoma (Raji) cells from normal human red blood cells (RBCs), mixed in an isotonic solution, by utilizing a hydrogenated amorphous silicon-based optically-induced electrokinetics chip. A theoretical calculation of the polarization model for the two different types of cells is first presented. The differential velocity between the cell types, generated as a result of the optically-induced dielectrophoresis (ODEP) force is obtained using a finite element method. The theoretical results indicate that the two types of cells could be separated by using the ODEP force. Experimental results verified that the two types of cells can be separated by using two optically projected lines of different widths, with one projected line moving and the other line stationary, as the virtual electrodes for generating the ODEP force. Separation is achieved with these virtual electrodes using a bias potential of 20 V pp at a driving frequency of 50 kHz. To the best of our knowledge, this work is the first experimental validation of rapid separation of Raji cells from RBCs using optically-induced electrokinetics. © 2013 IEEE.

Language英语
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Document Type会议论文
Identifierhttp://ir.sia.cn/handle/173321/12412
Collection机器人学研究室
Corresponding AuthorLi WJ(李文荣)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.University of the Chinese Academy of Sciences, Beijing, China
3.Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan
4.Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong
5.Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing, China
Recommended Citation
GB/T 7714
Liang WF,Liu B,Liu LQ,et al. Dynamic separation of b-lymphoma cells from red blood cells using optically-induced electrokinetics[C]//Institute of Electrical and Electronics Engineers (IEEE); IEEE Nanotechnology Council (NTC); Peking University; Soochow University; Chinese Academy of Sciences. Washington, United States:IEEE Computer Society,2013:1253-1256.
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