The invention relates to a denture computer-aided design (CAD) model rebuilding method, which belongs to the technical field of complicated curve surface rebuilding and three-dimensional solid modeling. The denture CAD model rebuilding method comprises the following steps of: inputting cross-section data of a denture carrying out B spline surface fitting on the cross-section data rebuilding B pline surfaces of the axial surface and the jaw surface of the denture finely adjusting the shape of the B pline surfaces of the axial surface and the jaw surface of the denture by a node method sewing and substantiating the rebuilt B pline surfaces of the denture by Boolean operation and substantiation between the curve surfaces, and generating a denture CAD solid model and storing the denture CAD model. The denture CAD model rebuilding method has the advantages that the manufacture period of the denture solid model is shortened, and the manufacture precision of the denture prosthesis is improved. A B pline curve surface method is adopted for describing the completed outer surface of the denture, the shape of the outer surface of the denture is finely adjusted by the node method, the rebuilt axial surface and the jaw surface of the denture is sewed and substantiated through the Boolean operation of the curve surfaces, and the individual requirements of the denture of clinical dental patients are met.