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一种纳流控芯片及基于AFM的加工方法和应用
Alternative TitleNanofluidic chip, processing method based on atomic force microscopy (AFM), and application
焦念东; 王志迁; 董再励
Department机器人学研究室
Rights Holder中国科学院沈阳自动化研究所
Patent Agent沈阳科苑专利商标代理有限公司 21002
Country中国
Subtype发明
Status视为撤回
Abstract本发明公开一种纳流控芯片及基于AFM的加工方法和应用,所述芯片的两端设置两个储液池,每个储液池连有微米管道,所述两个微米管道间设置纳米管道,所述纳米管道两侧各设置与管道成垂直的电极。利用AFM探针加工出连通微米管道的纳米管道。在芯片储液池间施加一定电压,同时在管道两侧电极上施加一个小电压并测量电流信号的变化;当有物体在纳米管道中流动经过电极时,将产生电流的变化,对该信号检测可用于分析纳米材料的结构及物理特性。该纳流控芯片的加工及信号检测方法可应用于DNA分子的低成本、快速测序。
Other AbstractThe invention discloses a nanofluidic chip, a processing method based on atomic force microscopy (AFM), and application. Each of two ends of the chip is provided with a liquid storage tank each liquid storage tank is connected with a micron pipeline a nano pipeline is arranged between two micron pipelines and electrodes which are vertical to the pipelines are arranged on two sides of the nano pipeline. The nano pipeline which is communicated with the micron pipelines is processed by using an AFM probe. Certain voltage is applied between the liquid storage tanks of the chip, small voltage is applied to the electrodes on two sides of the pipelines simultaneously, and the change of a current signal is measured and when an object flows through the electrodes in the nano pipeline, current changes, and signal detection can be used for analyzing the structural and physical characteristics of a nano material. Processing and signal detection methods for the nanofluidic chip can applied to low-cost and quick sequencing of deoxyribose nucleic acid (DNA) molecules.
PCT Attributes
Application Date2010-12-30
2012-07-04
Application NumberCN201010614403.7
Open (Notice) NumberCN102539503A
Language中文
Contribution Rank1
Document Type专利
Identifierhttp://ir.sia.cn/handle/173321/13771
Collection机器人学研究室
Affiliation中国科学院沈阳自动化研究所
Recommended Citation
GB/T 7714
焦念东,王志迁,董再励. 一种纳流控芯片及基于AFM的加工方法和应用[P]. 2012-07-04.
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