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Development of microfluidic-based telemedicine for diabetes care and screening
Yao P(姚萍); Tong ZH(童兆宏); Zhan ZK(詹志坤); Hua JN(化建宁); Dong ZL(董再励)
作者部门机器人学研究室
关键词Chemiluminescence Immunoassay Diabetes Screening Insulin Detection Microfluidic System Telemedicine
发表期刊TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL
ISSN0142-3312
2013
卷号35期号:7页码:893-900
收录类别SCI ; EI
EI收录号20133816767396
WOS记录号WOS:000326173800005
产权排序1
资助机构This project is funded by the State Key Laboratory of Robotics (Grant No. RLZ200808; RLO200812) and the National High Technology Research and Development Program of China (Grant No. 2009AA04Z313). Support is also provided by the CAS/SAFEA International Partnership Program for Creative Research Teams.
摘要This paper describes a microfluidic-based telemedicine system for insulin detection and conveying the results digitally to physicians located off-site through the Internet. The communication infrastructure is designed to transfer the digital information from the assay site to established healthcare facilities where trained medical professionals can directly assist the detection process and provide diagnosis. The insulin detection device of the telemedicine system is an integrated polydimethysiloxane (PDMS) microfluidic device consisting of two pneumatic micropumps and one micromixer. The insulin detection protocol is based on microbeads-based double-antibody sandwich immunoassay coupled with luminal-hydrogen peroxide (H2O2) chemiluminescence. A photometer detects the peak value of the luminous intensity, which indicates the insulin concentration of the patient plasma sample tested. The calibration curves of the insulin detection protocol have been quantified. The insulin detection limit of the microfluidic system is 4x10(-10)mol/l, which meets the common requirement of the current clinical studies of diabetes. Multiple immune indicators of diabetes can potentially be detected synchronously by the microfluidic system, thus providing physicians with integrative results necessary for accurate diagnosis via the Internet. The combination of microfluidic devices and telemedicine strategy offers new opportunities for diabetes care and screening, especially in rural areas where patients must travel long distances to physicians for healthcare information that might be obtained more cost effectively by local, less-trained personnel.
语种英语
WOS标题词Science & Technology ; Technology
WOS类目Automation & Control Systems ; Instruments & Instrumentation
关键词[WOS]INSULIN ; MANAGEMENT ; INJECTION ; SYSTEMS ; TIME
WOS研究方向Automation & Control Systems ; Instruments & Instrumentation
引用统计
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/14071
专题机器人学研究室
通讯作者Yao P(姚萍)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Nanta Street 114#, Shenyang 110016, China
2.Graduate School of the Chinese Academy of Sciences, Beijing, China
3.Department of Mechanical Engineering, University of Arkansas, Fayetteville, AK, United States
4.Department of Automation Engineering, Northeastern University at Qinhuangdao, Qinhuangdao, China
推荐引用方式
GB/T 7714
Yao P,Tong ZH,Zhan ZK,et al. Development of microfluidic-based telemedicine for diabetes care and screening[J]. TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL,2013,35(7):893-900.
APA Yao P,Tong ZH,Zhan ZK,Hua JN,&Dong ZL.(2013).Development of microfluidic-based telemedicine for diabetes care and screening.TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL,35(7),893-900.
MLA Yao P,et al."Development of microfluidic-based telemedicine for diabetes care and screening".TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL 35.7(2013):893-900.
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