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Development of microfluidic-based telemedicine for diabetes care and screening
Yao P(姚萍); Tong ZH(童兆宏); Zhan ZK(詹志坤); Hua JN(化建宁); Dong ZL(董再励)
Department机器人学研究室
Source PublicationTRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL
ISSN0142-3312
2013
Volume35Issue:7Pages:893-900
Indexed BySCI ; EI
EI Accession number20133816767396
WOS IDWOS:000326173800005
Contribution Rank1
Funding OrganizationThis project is funded by the State Key Laboratory of Robotics (Grant No. RLZ200808; RLO200812) and the National High Technology Research and Development Program of China (Grant No. 2009AA04Z313). Support is also provided by the CAS/SAFEA International Partnership Program for Creative Research Teams.
KeywordChemiluminescence Immunoassay Diabetes Screening Insulin Detection Microfluidic System Telemedicine
AbstractThis paper describes a microfluidic-based telemedicine system for insulin detection and conveying the results digitally to physicians located off-site through the Internet. The communication infrastructure is designed to transfer the digital information from the assay site to established healthcare facilities where trained medical professionals can directly assist the detection process and provide diagnosis. The insulin detection device of the telemedicine system is an integrated polydimethysiloxane (PDMS) microfluidic device consisting of two pneumatic micropumps and one micromixer. The insulin detection protocol is based on microbeads-based double-antibody sandwich immunoassay coupled with luminal-hydrogen peroxide (H2O2) chemiluminescence. A photometer detects the peak value of the luminous intensity, which indicates the insulin concentration of the patient plasma sample tested. The calibration curves of the insulin detection protocol have been quantified. The insulin detection limit of the microfluidic system is 4x10(-10)mol/l, which meets the common requirement of the current clinical studies of diabetes. Multiple immune indicators of diabetes can potentially be detected synchronously by the microfluidic system, thus providing physicians with integrative results necessary for accurate diagnosis via the Internet. The combination of microfluidic devices and telemedicine strategy offers new opportunities for diabetes care and screening, especially in rural areas where patients must travel long distances to physicians for healthcare information that might be obtained more cost effectively by local, less-trained personnel.
Language英语
WOS HeadingsScience & Technology ; Technology
WOS SubjectAutomation & Control Systems ; Instruments & Instrumentation
WOS KeywordINSULIN ; MANAGEMENT ; INJECTION ; SYSTEMS ; TIME
WOS Research AreaAutomation & Control Systems ; Instruments & Instrumentation
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/14071
Collection机器人学研究室
Corresponding AuthorYao P(姚萍)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Nanta Street 114#, Shenyang 110016, China
2.Graduate School of the Chinese Academy of Sciences, Beijing, China
3.Department of Mechanical Engineering, University of Arkansas, Fayetteville, AK, United States
4.Department of Automation Engineering, Northeastern University at Qinhuangdao, Qinhuangdao, China
Recommended Citation
GB/T 7714
Yao P,Tong ZH,Zhan ZK,et al. Development of microfluidic-based telemedicine for diabetes care and screening[J]. TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL,2013,35(7):893-900.
APA Yao P,Tong ZH,Zhan ZK,Hua JN,&Dong ZL.(2013).Development of microfluidic-based telemedicine for diabetes care and screening.TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL,35(7),893-900.
MLA Yao P,et al."Development of microfluidic-based telemedicine for diabetes care and screening".TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL 35.7(2013):893-900.
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