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Alternative TitleNanorobot synchronously tracking voltage-induced changes of membrane character
张常麟; 李鹏; 谢艳鹏; 杨洋; 李广勇; 刘连庆
Source Publication科学通报
Contribution Rank1
Funding Organization国家自然科学基金(61175103,61327014);中国科学院装备研制项目;中国科学院-国家外国专家局创新团队国际合作伙伴计划资助
Keyword平面膜片钳 纳米操作机器人 杨氏模量 钳制电压
Other AbstractThe cell membrane characters including membrane Young’s modulus, membrane tension, mechanosensitivity of ion channel et al are important biomarkers in the living cell reseach. These properties have significance in perceptual system mediating by mechanical stimuli like sense touch or pain et al. However, knowledges based on cell membrane characters have been limited due to that there are no efficient research tools. In this paper, a cellular physiological information detect system integrating path-clamp technique and nanorobot technique has been developed which can be used to detect both physiological and physical signals on the cell simultaneously with supplying ultra-micro mechanical stimuli. This system contains a home-designed planar patch clamp module, a nanorobot based on the atomic force microscope (AFM) module and a microfluidic module. With this comprehensive system, an experiment to synchronously track the voltage-induced membrane Young’s modulus changes were proposed on the mouse neuroblastoma cell line (Neuro-2a). The experimental results show that the membrane gets softer when the clamping voltage goes up. Finally, a theoretical derivation was deduced to explain the experimental phenomenon.
Document Type期刊论文
Corresponding Author刘连庆
3.Department of Electrical and Computer Engineering University of Pittsburgh
Recommended Citation
GB/T 7714
张常麟,李鹏,谢艳鹏,等. 纳米操作机器人同步追踪电压诱导膜特性改变[J]. 科学通报,2013,58(S2):187-193.
APA 张常麟,李鹏,谢艳鹏,杨洋,李广勇,&刘连庆.(2013).纳米操作机器人同步追踪电压诱导膜特性改变.科学通报,58(S2),187-193.
MLA 张常麟,et al."纳米操作机器人同步追踪电压诱导膜特性改变".科学通报 58.S2(2013):187-193.
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