The utility model relates to the field of medical instruments and especially relates to a manipulation device for a digestive endoscopic handle. The manipulation device comprises a rotary mechanism, a large dialing wheel mechanism, a small dialing wheel mechanism, a button opening-closing switching mechanism and a housing. The large dialing wheel mechanism, the small dialing wheel mechanism and the button opening-closing switching mechanism are arranged in the housing. The rotary mechanism is connected with one end of the housing. A flexible tail end of the digestive endoscopic handle stretches out of the other end of the housing. The rotary mechanism drives the housing and further drives the digestive endoscopic handle to rotate via bevel gears. The large dialing wheel mechanism and the small dialing wheel mechanism respectively drive a large dialing wheel sleeve and a small dialing wheel sleeve to stir a large dialing wheel and a small dialing wheel of the digestive endoscopic handle in forward and reverse directions via synchronous belts and a limiting function is obtained. The button opening-closing switching mechanism helps to achieve pressing-down and restoring operation to a water supply button, a steam supply button and an attracting button of the digestive endoscopic handle via air cylinders and levers. The manipulation device for the digestive endoscopic handle has following beneficial effects: manual operation of doctors is replaced; and more accurate control and safety protection are achieved.