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Alternative TitleDevelopment and implementation of scanning ion conductance microscope
李鹏; 张常麟; 王文学; 刘连庆
Source Publication红外与激光工程
Indexed ByEI ; CSCD
EI Accession number20142917960085
Contribution Rank1
Funding Organization国家自然科学基金(61175103); 中国科学院科研装备研制项目(YZ201245); 中国科学院与国家外国专家局创新团队国际合作伙伴计划
Keyword扫描离子电导显微镜 活细胞无损成像 跳跃模式
Other AbstractHigh-resolution imaging of living cell at the micro-/nano-scale is important for life science research. It may help to observe biological activities of cells, and to detect cell responses to external stimuli and even movements of some protein molecules in cell membranes. However, there have not been effective methods to realize such objectives yet. Scanning ion conductance microscope (SICM) has been widely applied in many fields and is receiving increasing attention due to its non-contact, force-free, and high-resolution imaging features. Herein, a design of SICM, including hardware integration and scanning algorithms, was introduced from the point of view of system firstly; then the feasibility and effectiveness of the system was evaluated through comparison of PDMS gratings measurements by SICM and AFM; finally, in situ experiments of living-cell imaging in physiological environment had been carried out, and the topography of living neuro-2A cell had been successfully obtained. The well-established scanning ion conductance microscope will provide an effective tool for investigating functional mechanism and microstructure on the surface of living biological samples.
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Document Type期刊论文
Corresponding Author刘连庆
Recommended Citation
GB/T 7714
李鹏,张常麟,王文学,等. 扫描离子电导显微镜的研制与实现[J]. 红外与激光工程,2014,43(6):1894-1898.
APA 李鹏,张常麟,王文学,&刘连庆.(2014).扫描离子电导显微镜的研制与实现.红外与激光工程,43(6),1894-1898.
MLA 李鹏,et al."扫描离子电导显微镜的研制与实现".红外与激光工程 43.6(2014):1894-1898.
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