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Regulating the mechanical properties of cells using a non-UV light-addressable hydrogel patterning process
Liu N(刘娜); Zhang CL(张常麟); Liu LQ(刘连庆); Wang YC(王越超); Gwo-Bin Lee; Li WJ(李文荣)
作者部门机器人学研究室
会议名称2014 IEEE International Conference on Robotics and Automation (ICRA 2014)
会议日期May 31 - June 7, 2014
会议地点HongKong, China
会议录名称2014 IEEE International Conference on Robotics and Automation (ICRA 2014)
出版者IEEE
出版地Piscataway, NJ, USA
2014
页码5866-5870
收录类别EI ; CPCI(ISTP)
EI收录号20152000853210
WOS记录号WOS:000377221105136
产权排序1
ISBN号978-1-4799-3685-4
摘要

The determination of the mechanical properties of cells plays an important role in biological studies and has gained acceptance recently as a possible label-free biomarker for cell status determination or diseases detection. Investigations on how external cellular properties affect cell mechanics are helpful in understanding cell disease processes and cell morphogenesis, which are of large significance in medical science. Although most researchers have focused on individual cell mechanics, or the effect of substrate stiffness on cells, cell mechanical response due to interactions among cells is yet to be examined. A reason for this is that the study of cell mechanical response to cell shape requires one to use a cell patterning process. However, existing cell patterning methods are very complex and time-consuming. In this paper, we describe a practical and rapid technique that can easily pattern cells into desired shapes, which allows investigations of the effect of external environment on cell stiffness. In the new technique, Poly-(ethylene) glycol diacrylate (PEGDA) hydrogel film with thickness 70–100 nm is controllably patterned on a hydrogenated amorphous silicon (a-Si:H) substrate by polymerizing PEGDA molecules in-situ using programmable visual light patterns. The idea is to enable the confinement of cells cultured on the hydrogels into special areas. The elastic modulus of the patterned cells is measured using an atomic force microscope. Experimental results have demonstrated the versatility of the technique as a tool for cell pattering and exploration of cell mechanics under external mechanical stimuli.

语种英语
引用统计
文献类型会议论文
条目标识符http://ir.sia.cn/handle/173321/15393
专题机器人学研究室
通讯作者Liu N(刘娜)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences (CAS), China
2.Department of Power Mechanical Engineering, National Tsinghua University, Hsinchu, Taiwan
3.Dept. of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong
推荐引用方式
GB/T 7714
Liu N,Zhang CL,Liu LQ,et al. Regulating the mechanical properties of cells using a non-UV light-addressable hydrogel patterning process[C]. Piscataway, NJ, USA:IEEE,2014:5866-5870.
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