With the development of minimally invasive surgery, virtual surgery has an increasingly broad application prospects. As the core technology of virtual surgery, force feedback directly affects the sense of immersion in virtual surgery. The classic bounding box collision detection algorithms are compared in this paper, and the sphere bounding box collision detection algorithm is then adopted. A precise force feedback model is established to simulate the flexible collision impact in vascular interventional surgery. The simulation is of high accuracy and real-time capability.