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Amplitude Modulation Mode of Scanning Ion Conductance Microscopy
Li P(李鹏); Liu LQ(刘连庆); Yang Y(杨洋); Zhou L(周磊); Wang D(王栋); Wang YC(王越超); Li GY(李广勇)
作者部门机器人学研究室
关键词Scanning Ion Conductance Microscopy Am Mode Ac Voltage Capacitance Compensation Nanoscale Imaging
发表期刊Journal of Laboratory Automation
ISSN2211-0682
2015
卷号20期号:4页码:457-462
收录类别SCI ; EI
EI收录号20153301165152
WOS记录号WOS:000358333800012
产权排序1
资助机构National Natural Science Foundation of China [61433017, 61327014] ; Chinese Academy of Sciences [YZ201245] ; CAS FEA International Partnership Program for Creative Research Teams
摘要Live-cell imaging at the nanoscale resolution is a hot research topic in the field of life sciences for the direct observation of cellular biological activity. Scanning ion conductance microscopy (SICM) is one of the few effective imaging tools for live-cell imaging at the nanoscale resolution. However, there are various problems in existing scanning modes. The hopping and AC modes suffer from low speed, whereas the DC mode is prone to instability because of the DC drift and external electrical interference. In this article, we propose an amplitude modulation (AM) mode of SICM, which employs an AC voltage to enhance the stability and improve the scanning speed. In this AM mode, we introduce a capacitance compensation method to eliminate capacitance effect and use the amplitude of the AC current component to control the tip movement. Experimental results on polydimethylsiloxane samples verify the validity of the AM mode and demonstrate an improved performance of both speed and stability of this new mode.
语种英语
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS类目Biochemical Research Methods ; Chemistry, Analytical
关键词[WOS]ATOMIC-FORCE MICROSCOPY ; NANOSCALE ; CELLS ; AFM
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/16852
专题机器人学研究室
通讯作者Liu LQ(刘连庆); Li GY(李广勇)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.University of Chinese Academy of Sciences, Beijing, China
3.Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, United States
推荐引用方式
GB/T 7714
Li P,Liu LQ,Yang Y,et al. Amplitude Modulation Mode of Scanning Ion Conductance Microscopy[J]. Journal of Laboratory Automation,2015,20(4):457-462.
APA Li P.,Liu LQ.,Yang Y.,Zhou L.,Wang D.,...&Li GY.(2015).Amplitude Modulation Mode of Scanning Ion Conductance Microscopy.Journal of Laboratory Automation,20(4),457-462.
MLA Li P,et al."Amplitude Modulation Mode of Scanning Ion Conductance Microscopy".Journal of Laboratory Automation 20.4(2015):457-462.
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