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题名: Super-resolution endoscopy for real-time wide-field imaging
作者: Wang FF(王飞飞); Lai, Hok Sum Sam; Liu LQ(刘连庆); Li P(李盼); Yu HB(于海波); Liu Z(刘柱); Wang YC(王越超); Li WR(李文荣)
作者部门: 机器人学研究室
刊名: OPTICS EXPRESS
ISSN号: 1094-4087
出版日期: 2015
卷号: 23, 期号:13, 页码:16803-16811
收录类别: SCI ; EI
产权排序: 1
项目资助者: NSFC/RGC Joint Research Scheme [51461165501, CityU132/14] ; CAS-Croucher Joint Lab Scheme [9500011] ; CAS FEA International Partnership Program for Creative Research Teams ; Hong Kong Research Grants Council [CityU 116912]
摘要: Resolving subcellular structures in vitro beyond optical diffraction barrier by a light microscope has achieved significant development since the advancement of super-resolution fluorescence microscopes, such as stimulated emission depletion (STED) microscopy, stochastic optical reconstruction microscopy (STORM) and photoactivated localization microscopy (PALM). However, the resolution of observation in deep and dense in vivo tissues is still confined to cellular level presently, and hence, exploring image details at subcellular level or even beyond organelle level in vivo has continued to attract much research attention. Currently, endoscopy provides an effective way to achieve in vivo observations and is compatible with mature optical microscopy technologies, but its resolution is usually confined to similar to 1 mu m. Here we report a new endoscopy method by functionalizing graded-index (GRIN) lens with microspheres for real-time white-light or fluorescent super-resolution imaging. The capability of resolving objects with feature size of similar to lambda/5, which breaks the diffraction barrier of traditional GRIN lens based endoscopes by a factor of two, has been demonstrated by using this superresolution endoscopy method. Further development of such a superresolution endoscopy technique may provide new opportunities for in vivo life sciences studies.
语种: 英语
WOS记录号: WOS:000358543300032
WOS标题词: Science & Technology ; Physical Sciences
类目[WOS]: Optics
关键词[WOS]: FLUORESCENCE MICROENDOSCOPY ; HIGH-SPEED ; MICROSCOPY ; MICROSPHERE ; RESOLUTION ; NANOSCOPE ; BREAKING ; PHOTON ; DEPTH ; LIMIT
研究领域[WOS]: Optics
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内容类型: 期刊论文
URI标识: http://ir.sia.cn/handle/173321/16853
Appears in Collections:机器人学研究室_期刊论文

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