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Nanoscale monitoring of drug actions on cell membrane using atomic force microscopy
Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
作者部门机器人学研究室
关键词Atomic Force Microscopy Single-cell Technique Nanometer Scale Drug-target Interaction Cell Mechanics Cell Elasticity
发表期刊ACTA PHARMACOLOGICA SINICA
ISSN1671-4083
2015
卷号36期号:7页码:769-782
收录类别SCI ; CSCD
WOS记录号WOS:000357477600001
CSCD记录号CSCD:5474147
产权排序1
资助机构National Natural Science Foundation of China [61175103, 61375107, 61327014, 61433017] ; State Key Laboratory of Robotics [2014-Z07] ; CAS FEA International Partnership Program for Creative Research Teams
摘要Knowledge of the nanoscale changes that take place in individual cells in response to a drug is useful for understanding the drug action. However, due to the lack of adequate techniques, such knowledge was scarce until the advent of atomic force microscopy (AFM), which is a multifunctional tool for investigating cellular behavior with nanometer resolution under near-physiological conditions. In the past decade, researchers have applied AFM to monitor the morphological and mechanical dynamics of individual cells following drug stimulation, yielding considerable novel insight into how the drug molecules affect an individual cell at the nanoscale. In this article we summarize the representative applications of AFM in characterization of drug actions on cell membrane, including topographic imaging, elasticity measurements, molecular interaction quantification, native membrane protein imaging and manipulation, etc. The challenges that are hampering the further development of AFM for studies of cellular activities are aslo discussed.
语种英语
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
WOS类目Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
关键词[WOS]MOLECULAR RECOGNITION EVENTS ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; RECEPTOR TYROSINE KINASE ; RESEARCH-AND-DEVELOPMENT ; RED-BLOOD-CELLS ; LIVING CELLS ; CANCER-CELLS ; MECHANICAL-PROPERTIES ; CONFORMATIONAL-CHANGES ; SINGLE PROTEINS
WOS研究方向Chemistry ; Pharmacology & Pharmacy
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/16857
专题机器人学研究室
通讯作者Liu LQ(刘连庆); Xi N(席宁)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, USA
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GB/T 7714
Li M,Liu LQ,Xi N,et al. Nanoscale monitoring of drug actions on cell membrane using atomic force microscopy[J]. ACTA PHARMACOLOGICA SINICA,2015,36(7):769-782.
APA Li M,Liu LQ,Xi N,&Wang YC.(2015).Nanoscale monitoring of drug actions on cell membrane using atomic force microscopy.ACTA PHARMACOLOGICA SINICA,36(7),769-782.
MLA Li M,et al."Nanoscale monitoring of drug actions on cell membrane using atomic force microscopy".ACTA PHARMACOLOGICA SINICA 36.7(2015):769-782.
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