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Nanoscale monitoring of drug actions on cell membrane using atomic force microscopy
Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
Department机器人学研究室
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN1671-4083
2015
Volume36Issue:7Pages:769-782
Indexed BySCI ; CSCD
WOS IDWOS:000357477600001
CSCD IDCSCD:5474147
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China [61175103, 61375107, 61327014, 61433017] ; State Key Laboratory of Robotics [2014-Z07] ; CAS FEA International Partnership Program for Creative Research Teams
KeywordAtomic Force Microscopy Single-cell Technique Nanometer Scale Drug-target Interaction Cell Mechanics Cell Elasticity
AbstractKnowledge of the nanoscale changes that take place in individual cells in response to a drug is useful for understanding the drug action. However, due to the lack of adequate techniques, such knowledge was scarce until the advent of atomic force microscopy (AFM), which is a multifunctional tool for investigating cellular behavior with nanometer resolution under near-physiological conditions. In the past decade, researchers have applied AFM to monitor the morphological and mechanical dynamics of individual cells following drug stimulation, yielding considerable novel insight into how the drug molecules affect an individual cell at the nanoscale. In this article we summarize the representative applications of AFM in characterization of drug actions on cell membrane, including topographic imaging, elasticity measurements, molecular interaction quantification, native membrane protein imaging and manipulation, etc. The challenges that are hampering the further development of AFM for studies of cellular activities are aslo discussed.
Language英语
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS KeywordMOLECULAR RECOGNITION EVENTS ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; RECEPTOR TYROSINE KINASE ; RESEARCH-AND-DEVELOPMENT ; RED-BLOOD-CELLS ; LIVING CELLS ; CANCER-CELLS ; MECHANICAL-PROPERTIES ; CONFORMATIONAL-CHANGES ; SINGLE PROTEINS
WOS Research AreaChemistry ; Pharmacology & Pharmacy
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Cited Times:3[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/16857
Collection机器人学研究室
Corresponding AuthorLiu LQ(刘连庆); Xi N(席宁)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, USA
Recommended Citation
GB/T 7714
Li M,Liu LQ,Xi N,et al. Nanoscale monitoring of drug actions on cell membrane using atomic force microscopy[J]. ACTA PHARMACOLOGICA SINICA,2015,36(7):769-782.
APA Li M,Liu LQ,Xi N,&Wang YC.(2015).Nanoscale monitoring of drug actions on cell membrane using atomic force microscopy.ACTA PHARMACOLOGICA SINICA,36(7),769-782.
MLA Li M,et al."Nanoscale monitoring of drug actions on cell membrane using atomic force microscopy".ACTA PHARMACOLOGICA SINICA 36.7(2015):769-782.
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