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Finite element simulation of stress relaxation process in living cells
Wei FN(魏发南); Zhou PL(周培林); Li GY(李广勇); Liu LQ(刘连庆)
作者部门机器人学研究室
会议名称10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015
会议日期April 7, 2015 - April 11, 2015
会议地点Xi'an, China
会议主办者Institute of Electrical and Electronics Engineers Inc.
会议录名称2015 IEEE 10th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015
出版者IEEE
出版地Piscataway, NJ, USA
2015
页码67-71
收录类别EI ; CPCI(ISTP)
EI收录号20153401190209
WOS记录号WOS:000380505700017
产权排序1
ISBN号978-1-4673-6695-3
关键词Cell Mechanics Finite Element Simulation Viscoelastic
摘要In this manuscript, we investigated the fundamental mechanism of stress relaxation phenomenon by employing finite element simulation. Through finite element simulations, the evolution of stress distribution, deformation field and the interaction force was wholly recorded during both the loading and stress relaxation stages. With the developed simulation model, the sensitivity of force-time curves on cell height and substrate stiffness was thoroughly studied by changing the thickness of cell and Young's modulus of the substrate. The simulation results indicated that the variation of cell height leads to the significant change of F-t curve's magnitude but tiny deviation of the curve's shape. And the influence originates from the substrate can be totally eliminated with relatively hard substrate. Finally, using the viscoelastic parameters extracted from actual stress relaxation experiment, the dynamic mechanical behavior of L929 cells is simulated and investigated. A comparison between the experimental and simulation F-t curves demonstrated the effectiveness of the proposed finite element simulation approach.
语种英语
引用统计
文献类型会议论文
条目标识符http://ir.sia.cn/handle/173321/16899
专题机器人学研究室
通讯作者Li GY(李广勇); Liu LQ(刘连庆)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.University of Chinese Academy of Sciences, Beijing, China
3.Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, United States
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Wei FN,Zhou PL,Li GY,et al. Finite element simulation of stress relaxation process in living cells[C]//Institute of Electrical and Electronics Engineers Inc.. Piscataway, NJ, USA:IEEE,2015:67-71.
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