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Finite element simulation of stress relaxation process in living cells
Wei FN(魏发南); Zhou PL(周培林); Li GY(李广勇); Liu LQ(刘连庆)
Department机器人学研究室
Conference Name10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015
Conference DateApril 7, 2015 - April 11, 2015
Conference PlaceXi'an, China
Author of SourceInstitute of Electrical and Electronics Engineers Inc.
Source Publication2015 IEEE 10th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015
PublisherIEEE
Publication PlacePiscataway, NJ, USA
2015
Pages67-71
Indexed ByEI ; CPCI(ISTP)
EI Accession number20153401190209
WOS IDWOS:000380505700017
Contribution Rank1
ISBN978-1-4673-6695-3
KeywordCell Mechanics Finite Element Simulation Viscoelastic
AbstractIn this manuscript, we investigated the fundamental mechanism of stress relaxation phenomenon by employing finite element simulation. Through finite element simulations, the evolution of stress distribution, deformation field and the interaction force was wholly recorded during both the loading and stress relaxation stages. With the developed simulation model, the sensitivity of force-time curves on cell height and substrate stiffness was thoroughly studied by changing the thickness of cell and Young's modulus of the substrate. The simulation results indicated that the variation of cell height leads to the significant change of F-t curve's magnitude but tiny deviation of the curve's shape. And the influence originates from the substrate can be totally eliminated with relatively hard substrate. Finally, using the viscoelastic parameters extracted from actual stress relaxation experiment, the dynamic mechanical behavior of L929 cells is simulated and investigated. A comparison between the experimental and simulation F-t curves demonstrated the effectiveness of the proposed finite element simulation approach.
Language英语
Citation statistics
Document Type会议论文
Identifierhttp://ir.sia.cn/handle/173321/16899
Collection机器人学研究室
Corresponding AuthorLi GY(李广勇); Liu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.University of Chinese Academy of Sciences, Beijing, China
3.Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, United States
Recommended Citation
GB/T 7714
Wei FN,Zhou PL,Li GY,et al. Finite element simulation of stress relaxation process in living cells[C]//Institute of Electrical and Electronics Engineers Inc.. Piscataway, NJ, USA:IEEE,2015:67-71.
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