The invention relates to pleating equipment for ham sausage plastic casings, in particular to a ham sausage plastic casing double-wheel pleating machine. A drive motor and a guiding sliding table are respectively installed on the machine body, a swing cylinder is arranged on the guiding sliding table, core shafts are arranged on the swing cylinder and are driven by the swing cylinder to switch between a pleating station and a discharge station. Pleating wheels and feed wheels are respectively installed on the machine body rotatably, and are connected to a pleating wheel drive motor respectively through a transmission device and are driven to rotate by the pleating wheel drive motor. A discharge chuck, a cutting knife and a negative pressure mechanism are respectively mounted on the machine body, the cutting knife and the negative pressure mechanism are located at the pleating station, the discharge chuck is located at the discharge station, a casing wheel disc is mounted on the machine body, the casing on the casing wheel disc passes through the feed wheels and pleating wheels in order, and the open end of the casing is adsorbed and positioned by the negative pressure mechanism. The ham sausage plastic casing double-wheel pleating machine provided by the invention has the advantages of high efficiency, high automation degree and reliable quality, and is suitable for continuous use in production with strict environmental requirements and high strength production tempo.