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Selective pattern of cancer cell accumulation and growth using UV modulating printing of hydrogels
Yang WG(杨文广); Yu HB(于海波); Wei FN(魏发南); Li GX(李恭新); Wang YC(王越超); Liu LQ(刘连庆)
Department机器人学研究室
Source PublicationBiomedical Microdevices
ISSN1387-2176
2015
Volume17Issue:6Pages:1-8
Indexed BySCI ; EI
EI Accession number20154201389028
WOS IDWOS:000365704800003
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China (Project No. 61302003,61475183 and 61503258), the CAS FEA International Partnership Program for Creative Research Teams and the Instrument Developing Project of the Chinese Academy of Sciences (Grant No. yz201339).
KeywordCell Pattern Microfabrication Bioengineering Bioprinting
AbstractFabrication of extracellular microenvironment for cancer cell growth in vitro is an indispensable technique to precisely control the cell spatial arrangement and proliferation for cell-behavior research. Current micropatterning methods usually require relatively complicated operations, which makes it difficult to investigate the effects of different cell growth patterns. This manuscript proposes a DMD-based projection technique to quickly pattern a poly(ethylene) glycol diacrylate (PEGDA)-based hydrogel on a common glass substrate. Using this method, we can effectively control the growth patterns of cells. Compared with these traditional methods which employ digital dynamic mask, polymerization of PEGDA solution can be used to create arbitrary shaped microstructures with high efficiency, flexibility and repeatability. The duration of UV exposure is less than 10 s through controlling the projected illumination pattern. The ability of patterned PEGDA-coated film to hinder cell adhesion makes it possible to control area over which cells attach. In our experiments, we take advantage of the blank area to pattern cells, which allows cells to grow in various pre-designed shapes and sizes. And the patterning cells have a high viability after culturing for several days. Interestingly, we found that the restricted space could stiffen and strengthen the cells. These results indicate that cells and extracellular microenvironment can influence each other. © 2015, Springer Science+Business Media New York.
Language英语
WOS HeadingsScience & Technology ; Technology
WOS SubjectEngineering, Biomedical ; Nanoscience & Nanotechnology
WOS KeywordATOMIC-FORCE MICROSCOPY ; SELF-ASSEMBLED MONOLAYERS ; MECHANICAL-PROPERTIES ; BREAST-CANCER ; LIVING CELLS ; ADHESION ; LITHOGRAPHY ; DIFFERENTIATION ; MICROSTRUCTURES ; PEPTIDES
WOS Research AreaEngineering ; Science & Technology - Other Topics
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/17140
Collection机器人学研究室
Corresponding AuthorYu HB(于海波); Liu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.University of Chinese Academy of Sciences, Beijing, China
Recommended Citation
GB/T 7714
Yang WG,Yu HB,Wei FN,et al. Selective pattern of cancer cell accumulation and growth using UV modulating printing of hydrogels[J]. Biomedical Microdevices,2015,17(6):1-8.
APA Yang WG,Yu HB,Wei FN,Li GX,Wang YC,&Liu LQ.(2015).Selective pattern of cancer cell accumulation and growth using UV modulating printing of hydrogels.Biomedical Microdevices,17(6),1-8.
MLA Yang WG,et al."Selective pattern of cancer cell accumulation and growth using UV modulating printing of hydrogels".Biomedical Microdevices 17.6(2015):1-8.
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