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3-D Non-UV Digital Printing of Hydrogel Microstructures by Optically Controlled Digital Electropolymerization
Liu N(刘娜); Li P(李盼); Wang YC(王越超); Liu LQ(刘连庆); Li GB(李国斌); Li WJ(李文荣)
作者部门机器人学研究室
关键词Three-dimensional Micro Structures Micro Fabrication Tissue Engineering Biopolymer
发表期刊Journal of Microelectromechanical Systems
ISSN1057-7157
2015
卷号24期号:6页码:2128-2135
收录类别SCI ; EI
EI收录号20154001324467
WOS记录号WOS:000365987000052
产权排序1
资助机构National Natural Science Foundation of China (NSFC) under Project 61302003, in part by the NSFC/Research Grants Council Joint Research Scheme under Project 5141101088, in part the Chinese Academy of Sciences (CAS)–Croucher Funding Scheme through Joint Laboratories under Project 9500011, and in part by the CAS Foreign Experts Affairs International Partnership Program for Creative Research Teams.
摘要A technique using digital masks without ultraviolet light to rapidly print 3-D biopolymer structures with complex microarchitectures in a microfluidic chip has been demonstrated. In this approach, a customized system is used to project light images on a photoconductive substrate in order to create localized virtual electrodes when an alternating electric field is applied across the fluidic medium in an optically controlled digital electropolymerization chip. Upon these virtual electrodes, the localized electric fields are generated, which could activate the polymerization of acrylate-based molecules, such as poly(ethylene glycol) diacrylate (PEGDA), to form microstructures with the same shapes as the projected light images. We have demonstrated that the 3-D PEGDA microstructures with the customized shapes could be fabricated rapidly through a layer-by-layer process by applying a series of digital masks (projected light images). With our current projection and microscopy system, the fabrication of microhydrogel structures with a lateral resolution of 3 $mu text{m}$ and an adjustable thickness ranging from tens of nanometers to hundreds of micrometers has been demonstrated. In summary, this novel technique provides an efficient process for the rapid printing of the 3-D biopolymer-based microstructures, and could enable many future applications in a mechanoanalysis of cancer cells, tissue engineering, and drug screening.
语种英语
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/17449
专题机器人学研究室
通讯作者Liu LQ(刘连庆); Li WJ(李文荣)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.University of the Chinese Academy of Sciences, Beijing, China
3.Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan
4.Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong
5.Shenyang Institute of Automaton, Chinese Academy of Sciences, Shenyang, China
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GB/T 7714
Liu N,Li P,Wang YC,et al. 3-D Non-UV Digital Printing of Hydrogel Microstructures by Optically Controlled Digital Electropolymerization[J]. Journal of Microelectromechanical Systems,2015,24(6):2128-2135.
APA Liu N,Li P,Wang YC,Liu LQ,Li GB,&Li WJ.(2015).3-D Non-UV Digital Printing of Hydrogel Microstructures by Optically Controlled Digital Electropolymerization.Journal of Microelectromechanical Systems,24(6),2128-2135.
MLA Liu N,et al."3-D Non-UV Digital Printing of Hydrogel Microstructures by Optically Controlled Digital Electropolymerization".Journal of Microelectromechanical Systems 24.6(2015):2128-2135.
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