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题名: 3-D Non-UV Digital Printing of Hydrogel Microstructures by Optically Controlled Digital Electropolymerization
作者: Liu N(刘娜); Li P(李盼); Wang YC(王越超); Liu LQ(刘连庆); Li GB(李国斌); Li WR(李文荣)
作者部门: 机器人学研究室
关键词: Three-dimensional micro structures ; micro fabrication ; tissue engineering ; biopolymer
刊名: Journal of Microelectromechanical Systems
ISSN号: 1057-7157
出版日期: 2015
卷号: 24, 期号:6, 页码:2128-2135
收录类别: SCI ; EI
产权排序: 1
项目资助者: National Natural Science Foundation of China (NSFC) under Project 61302003, in part by the NSFC/Research Grants Council Joint Research Scheme under Project 5141101088, in part the Chinese Academy of Sciences (CAS)–Croucher Funding Scheme through Joint Laboratories under Project 9500011, and in part by the CAS Foreign Experts Affairs International Partnership Program for Creative Research Teams.
摘要: A technique using digital masks without ultraviolet light to rapidly print 3-D biopolymer structures with complex microarchitectures in a microfluidic chip has been demonstrated. In this approach, a customized system is used to project light images on a photoconductive substrate in order to create localized virtual electrodes when an alternating electric field is applied across the fluidic medium in an optically controlled digital electropolymerization chip. Upon these virtual electrodes, the localized electric fields are generated, which could activate the polymerization of acrylate-based molecules, such as poly(ethylene glycol) diacrylate (PEGDA), to form microstructures with the same shapes as the projected light images. We have demonstrated that the 3-D PEGDA microstructures with the customized shapes could be fabricated rapidly through a layer-by-layer process by applying a series of digital masks (projected light images). With our current projection and microscopy system, the fabrication of microhydrogel structures with a lateral resolution of 3 $mu text{m}$ and an adjustable thickness ranging from tens of nanometers to hundreds of micrometers has been demonstrated. In summary, this novel technique provides an efficient process for the rapid printing of the 3-D biopolymer-based microstructures, and could enable many future applications in a mechanoanalysis of cancer cells, tissue engineering, and drug screening.
语种: 英语
WOS记录号: WOS:000365987000052
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sia.cn/handle/173321/17449
Appears in Collections:机器人学研究室_期刊论文

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Recommended Citation:
Liu N,Li P,Wang YC,et al. 3-D Non-UV Digital Printing of Hydrogel Microstructures by Optically Controlled Digital Electropolymerization[J]. Journal of Microelectromechanical Systems,2015,24(6):2128-2135.
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