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题名: Applications of Atomic Force Microscopy in Exploring Drug Actions in Lymphoma-Targeted Therapy at the Nanoscale
作者: Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
作者部门: 机器人学研究室
关键词: Atomic force microscopy ; Lymphoma ; Cell ; Rituximab ; Drug ; Nanoscale
刊名: BioNanoScience
ISSN号: 2191-1630
出版日期: 2016
卷号: 6, 期号:1, 页码:22-32
收录类别: EI
产权排序: 1
项目资助者: National Natural Science Foundation of China (61503372, 61522312, 61175103, 61375107, 61327014, and 61433017), the Research Fund of the State Key Laboratory of Robotics (no. 2014-Z07), and the CAS FEA International Partnership Program for Creative Research Teams
摘要: Rituximab, a monoclonal antibody against the CD20 molecule expressed on B cells, has revolutionized the treatment of B cell lymphomas. The use of rituximab significantly improves the long-term survival rates of lymphoma patients. However, there are still many patients who develop resistance to rituximab. Hence, the urgent need is enhancing the potency of anti-CD20 antibodies beyond that achieved with rituximab to provide effective therapies for more patients. Traditional studies about the killing mechanisms of rituximab are commonly based on optical microscopy, which cannot reveal the detailed situations due to the limit of 200-nm resolution. Quantitatively investigating the actions of rituximab at the nanoscale is still scarce. The advent of atomic force microscopy (AFM) provides a powerful and versatile platform for in situ investigating the nanoscale behaviors of individual live cells. The applications of AFM in life sciences in the past decade have yielded a lot of novel insights into cell biology and related diseases. In this article, the typical applications (e.g., ultra-microstructures, mechanical properties, and molecular recognition) of AFM in investigating the three killing mechanisms of rituximab at the nanoscale are summarized; the challenges facing AFM single-cell assay and its future directions are also discussed.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.sia.cn/handle/173321/17714
Appears in Collections:机器人学研究室_期刊论文

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Recommended Citation:
Li M,Liu LQ,Xi N,et al. Applications of Atomic Force Microscopy in Exploring Drug Actions in Lymphoma-Targeted Therapy at the Nanoscale[J]. BioNanoScience,2016,6(1):22-32.
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文件名: Applications of Atomic Force Microscopy in Exploring Drug Actions in Lymphoma-Targeted Therapy at the Nanoscale.pdf
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