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Applications of Atomic Force Microscopy in Exploring Drug Actions in Lymphoma-Targeted Therapy at the Nanoscale
Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
Department机器人学研究室
Source PublicationBioNanoScience
ISSN2191-1630
2016
Volume6Issue:1Pages:22-32
Indexed ByEI
EI Accession number20161002077532
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China (61503372, 61522312, 61175103, 61375107, 61327014, and 61433017), the Research Fund of the State Key Laboratory of Robotics (no. 2014-Z07), and the CAS FEA International Partnership Program for Creative Research Teams
KeywordAtomic Force Microscopy Lymphoma Cell Rituximab Drug Nanoscale
AbstractRituximab, a monoclonal antibody against the CD20 molecule expressed on B cells, has revolutionized the treatment of B cell lymphomas. The use of rituximab significantly improves the long-term survival rates of lymphoma patients. However, there are still many patients who develop resistance to rituximab. Hence, the urgent need is enhancing the potency of anti-CD20 antibodies beyond that achieved with rituximab to provide effective therapies for more patients. Traditional studies about the killing mechanisms of rituximab are commonly based on optical microscopy, which cannot reveal the detailed situations due to the limit of 200-nm resolution. Quantitatively investigating the actions of rituximab at the nanoscale is still scarce. The advent of atomic force microscopy (AFM) provides a powerful and versatile platform for in situ investigating the nanoscale behaviors of individual live cells. The applications of AFM in life sciences in the past decade have yielded a lot of novel insights into cell biology and related diseases. In this article, the typical applications (e.g., ultra-microstructures, mechanical properties, and molecular recognition) of AFM in investigating the three killing mechanisms of rituximab at the nanoscale are summarized; the challenges facing AFM single-cell assay and its future directions are also discussed.
Language英语
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/17714
Collection机器人学研究室
Corresponding AuthorLiu LQ(刘连庆); Xi N(席宁)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, United States
Recommended Citation
GB/T 7714
Li M,Liu LQ,Xi N,et al. Applications of Atomic Force Microscopy in Exploring Drug Actions in Lymphoma-Targeted Therapy at the Nanoscale[J]. BioNanoScience,2016,6(1):22-32.
APA Li M,Liu LQ,Xi N,&Wang YC.(2016).Applications of Atomic Force Microscopy in Exploring Drug Actions in Lymphoma-Targeted Therapy at the Nanoscale.BioNanoScience,6(1),22-32.
MLA Li M,et al."Applications of Atomic Force Microscopy in Exploring Drug Actions in Lymphoma-Targeted Therapy at the Nanoscale".BioNanoScience 6.1(2016):22-32.
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