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Regulation of breast cancer cell behaviours by the physical microenvironment constructed: Via projection microstereolithography
Yang WG(杨文广); Yu HB(于海波); Li GX(李恭新); Wang B(王博); Wang YC(王越超); Liu LQ(刘连庆)
作者部门机器人学研究室
发表期刊Biomaterials Science
ISSN2047-4830
2016
卷号4期号:5页码:863-870
收录类别SCI ; EI
EI收录号20162002385534
WOS记录号WOS:000375132800011
产权排序1
资助机构NationalNatural Science Foundation of China (project no. 61302003, 61475183 and 61503258), and the CAS FEA International Partnership Program for Creative Research Teams.
摘要A considerable number of studies have examined how intrinsic factors regulate breast cancer cell behaviours; however, physical microenvironmental cues may also modulate cellular morphology, proliferation, and migration and mechanical properties. In the present study, the surrounding microenvironment of breast cancer cells was constructed using projection microstereolithography, enabling the investigation of the external environment's effects on breast cancer cell behaviours. A poly(ethylene) glycol diacrylate (PEGDA) solution was polymerized by programmable ultraviolet exposure to create arbitrary shapes with high biocompatibility, efficiency, flexibility and repeatability, and the resistance to cell attachment enabled the PEGDA coated film to hinder cell adhesion, allowing cells to grow in specific patterns. Furthermore, breast cancer cell morphology and mechanical properties were modified by altering the microenvironment. Proliferation was higher in breast cancer as compared to normal cells, consistent with the primary characteristic of malignant tumors. Moreover, breast cancer cells migrated more rapidly when grown in a narrow channel as compared to a wider channel. These findings enhance our understanding of the role of the microenvironment in breast cancer cell behaviours and can provide a basis for developing effective anticancer therapies.
语种英语
WOS标题词Science & Technology ; Technology
WOS类目Materials Science, Biomaterials
关键词[WOS]TUMOR MICROENVIRONMENT ; HYDROGEL MICROSTRUCTURES ; MIGRATION ; SUBSTRATE ; STIFFNESS ; CONFINEMENT ; ADHESION ; PROLIFERATION ; LITHOGRAPHY ; FABRICATION
WOS研究方向Materials Science
引用统计
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/18638
专题机器人学研究室
通讯作者Yu HB(于海波); Liu LQ(刘连庆)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.University of Chinese Academy of Sciences, Beijing 100049, China
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GB/T 7714
Yang WG,Yu HB,Li GX,et al. Regulation of breast cancer cell behaviours by the physical microenvironment constructed: Via projection microstereolithography[J]. Biomaterials Science,2016,4(5):863-870.
APA Yang WG,Yu HB,Li GX,Wang B,Wang YC,&Liu LQ.(2016).Regulation of breast cancer cell behaviours by the physical microenvironment constructed: Via projection microstereolithography.Biomaterials Science,4(5),863-870.
MLA Yang WG,et al."Regulation of breast cancer cell behaviours by the physical microenvironment constructed: Via projection microstereolithography".Biomaterials Science 4.5(2016):863-870.
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