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Regulation of breast cancer cell behaviours by the physical microenvironment constructed: Via projection microstereolithography
Yang WG(杨文广); Yu HB(于海波); Li GX(李恭新); Wang B(王博); Wang YC(王越超); Liu LQ(刘连庆)
Department机器人学研究室
Source PublicationBiomaterials Science
ISSN2047-4830
2016
Volume4Issue:5Pages:863-870
Indexed BySCI ; EI
EI Accession number20162002385534
WOS IDWOS:000375132800011
Contribution Rank1
Funding OrganizationNationalNatural Science Foundation of China (project no. 61302003, 61475183 and 61503258), and the CAS FEA International Partnership Program for Creative Research Teams.
AbstractA considerable number of studies have examined how intrinsic factors regulate breast cancer cell behaviours; however, physical microenvironmental cues may also modulate cellular morphology, proliferation, and migration and mechanical properties. In the present study, the surrounding microenvironment of breast cancer cells was constructed using projection microstereolithography, enabling the investigation of the external environment's effects on breast cancer cell behaviours. A poly(ethylene) glycol diacrylate (PEGDA) solution was polymerized by programmable ultraviolet exposure to create arbitrary shapes with high biocompatibility, efficiency, flexibility and repeatability, and the resistance to cell attachment enabled the PEGDA coated film to hinder cell adhesion, allowing cells to grow in specific patterns. Furthermore, breast cancer cell morphology and mechanical properties were modified by altering the microenvironment. Proliferation was higher in breast cancer as compared to normal cells, consistent with the primary characteristic of malignant tumors. Moreover, breast cancer cells migrated more rapidly when grown in a narrow channel as compared to a wider channel. These findings enhance our understanding of the role of the microenvironment in breast cancer cell behaviours and can provide a basis for developing effective anticancer therapies.
Language英语
WOS HeadingsScience & Technology ; Technology
WOS SubjectMaterials Science, Biomaterials
WOS KeywordTUMOR MICROENVIRONMENT ; HYDROGEL MICROSTRUCTURES ; MIGRATION ; SUBSTRATE ; STIFFNESS ; CONFINEMENT ; ADHESION ; PROLIFERATION ; LITHOGRAPHY ; FABRICATION
WOS Research AreaMaterials Science
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Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/18638
Collection机器人学研究室
Corresponding AuthorYu HB(于海波); Liu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.University of Chinese Academy of Sciences, Beijing 100049, China
Recommended Citation
GB/T 7714
Yang WG,Yu HB,Li GX,et al. Regulation of breast cancer cell behaviours by the physical microenvironment constructed: Via projection microstereolithography[J]. Biomaterials Science,2016,4(5):863-870.
APA Yang WG,Yu HB,Li GX,Wang B,Wang YC,&Liu LQ.(2016).Regulation of breast cancer cell behaviours by the physical microenvironment constructed: Via projection microstereolithography.Biomaterials Science,4(5),863-870.
MLA Yang WG,et al."Regulation of breast cancer cell behaviours by the physical microenvironment constructed: Via projection microstereolithography".Biomaterials Science 4.5(2016):863-870.
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