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题名: Regulation of breast cancer cell behaviours by the physical microenvironment constructed: Via projection microstereolithography
作者: Yang WG(杨文广); Yu HB(于海波); Li GX(李恭新); Wang B(王博); Wang YC(王越超); Liu LQ(刘连庆)
作者部门: 机器人学研究室
刊名: Biomaterials Science
ISSN号: 2047-4830
出版日期: 2016
卷号: 4, 期号:5, 页码:863-870
收录类别: SCI ; EI
产权排序: 1
项目资助者: NationalNatural Science Foundation of China (project no. 61302003, 61475183 and 61503258), and the CAS FEA International Partnership Program for Creative Research Teams.
摘要: A considerable number of studies have examined how intrinsic factors regulate breast cancer cell behaviours; however, physical microenvironmental cues may also modulate cellular morphology, proliferation, and migration and mechanical properties. In the present study, the surrounding microenvironment of breast cancer cells was constructed using projection microstereolithography, enabling the investigation of the external environment's effects on breast cancer cell behaviours. A poly(ethylene) glycol diacrylate (PEGDA) solution was polymerized by programmable ultraviolet exposure to create arbitrary shapes with high biocompatibility, efficiency, flexibility and repeatability, and the resistance to cell attachment enabled the PEGDA coated film to hinder cell adhesion, allowing cells to grow in specific patterns. Furthermore, breast cancer cell morphology and mechanical properties were modified by altering the microenvironment. Proliferation was higher in breast cancer as compared to normal cells, consistent with the primary characteristic of malignant tumors. Moreover, breast cancer cells migrated more rapidly when grown in a narrow channel as compared to a wider channel. These findings enhance our understanding of the role of the microenvironment in breast cancer cell behaviours and can provide a basis for developing effective anticancer therapies.
语种: 英语
WOS记录号: WOS:000375132800011
WOS标题词: Science & Technology ; Technology
类目[WOS]: Materials Science, Biomaterials
关键词[WOS]: TUMOR MICROENVIRONMENT ; HYDROGEL MICROSTRUCTURES ; MIGRATION ; SUBSTRATE ; STIFFNESS ; CONFINEMENT ; ADHESION ; PROLIFERATION ; LITHOGRAPHY ; FABRICATION
研究领域[WOS]: Materials Science
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内容类型: 期刊论文
URI标识: http://ir.sia.cn/handle/173321/18638
Appears in Collections:机器人学研究室_期刊论文

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Recommended Citation:
Yang WG,Yu HB,Li GX,et al. Regulation of breast cancer cell behaviours by the physical microenvironment constructed: Via projection microstereolithography[J]. Biomaterials Science,2016,4(5):863-870.
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