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Fully Automated Quantification of Insulin Concentration Using a Microfluidic-Based Chemiluminescence Immunoassay
Yao P(姚萍); Liu Z(刘柱); Tung, Steve; Dong ZL(董再励); Liu LQ(刘连庆)
作者部门机器人学研究室
关键词Microfluidics Point-of-care Testing (Poct) Rapid Determination Insulin Chemiluminescence
发表期刊Journal of Laboratory Automation
ISSN2211-0682
2016
卷号21期号:3页码:387-393
收录类别SCI ; EI
EI收录号20162302464210
WOS记录号WOS:000377095200005
产权排序1
资助机构National Natural Science Foundation of China (Grant Nos. 61327014 and 61304251)
摘要A fully automated microfluidic-based detection system for the rapid determination of insulin concentration through a chemiluminescence immunoassay has been developed. The microfluidic chip used in the system is a double-layered polydimethylsiloxane device embedded with interconnecting micropumps, microvalves, and a micromixer. At a high injection rate of the developing solution, the chemiluminescence signal can be excited and measured within a short period of time. The integral value of the chemiluminescence light signal is used to determine the insulin concentration of the samples, and the results indicate that the measurement is accurate in the range from 1.5 pM to 391 pM. The entire chemiluminescence assay can be completed in less than 10 min. The fully automated microfluidic-based insulin detection system provides a useful platform for rapid determination of insulin in clinical diagnostics for diabetes, which is expected to become increasingly important for future point-of-care applications. 
语种英语
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS类目Biochemical Research Methods ; Chemistry, Analytical
关键词[WOS]TELEMEDICINE ; SYSTEM
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/18682
专题机器人学研究室
通讯作者Yao P(姚萍)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.University of Chinese Academy of Sciences, Beijing, China
3.Department of Mechanical Engineering, University of Arkansas, Fayetteville, AR, United States
推荐引用方式
GB/T 7714
Yao P,Liu Z,Tung, Steve,et al. Fully Automated Quantification of Insulin Concentration Using a Microfluidic-Based Chemiluminescence Immunoassay[J]. Journal of Laboratory Automation,2016,21(3):387-393.
APA Yao P,Liu Z,Tung, Steve,Dong ZL,&Liu LQ.(2016).Fully Automated Quantification of Insulin Concentration Using a Microfluidic-Based Chemiluminescence Immunoassay.Journal of Laboratory Automation,21(3),387-393.
MLA Yao P,et al."Fully Automated Quantification of Insulin Concentration Using a Microfluidic-Based Chemiluminescence Immunoassay".Journal of Laboratory Automation 21.3(2016):387-393.
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