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Fully Automated Quantification of Insulin Concentration Using a Microfluidic-Based Chemiluminescence Immunoassay
Yao P(姚萍); Liu Z(刘柱); Tung, Steve; Dong ZL(董再励); Liu LQ(刘连庆)
Department机器人学研究室
Source PublicationJournal of Laboratory Automation
ISSN2211-0682
2016
Volume21Issue:3Pages:387-393
Indexed BySCI ; EI
EI Accession number20162302464210
WOS IDWOS:000377095200005
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China (Grant Nos. 61327014 and 61304251)
KeywordMicrofluidics Point-of-care Testing (Poct) Rapid Determination Insulin Chemiluminescence
AbstractA fully automated microfluidic-based detection system for the rapid determination of insulin concentration through a chemiluminescence immunoassay has been developed. The microfluidic chip used in the system is a double-layered polydimethylsiloxane device embedded with interconnecting micropumps, microvalves, and a micromixer. At a high injection rate of the developing solution, the chemiluminescence signal can be excited and measured within a short period of time. The integral value of the chemiluminescence light signal is used to determine the insulin concentration of the samples, and the results indicate that the measurement is accurate in the range from 1.5 pM to 391 pM. The entire chemiluminescence assay can be completed in less than 10 min. The fully automated microfluidic-based insulin detection system provides a useful platform for rapid determination of insulin in clinical diagnostics for diabetes, which is expected to become increasingly important for future point-of-care applications. 
Language英语
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS KeywordTELEMEDICINE ; SYSTEM
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
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Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/18682
Collection机器人学研究室
Corresponding AuthorYao P(姚萍)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.University of Chinese Academy of Sciences, Beijing, China
3.Department of Mechanical Engineering, University of Arkansas, Fayetteville, AR, United States
Recommended Citation
GB/T 7714
Yao P,Liu Z,Tung, Steve,et al. Fully Automated Quantification of Insulin Concentration Using a Microfluidic-Based Chemiluminescence Immunoassay[J]. Journal of Laboratory Automation,2016,21(3):387-393.
APA Yao P,Liu Z,Tung, Steve,Dong ZL,&Liu LQ.(2016).Fully Automated Quantification of Insulin Concentration Using a Microfluidic-Based Chemiluminescence Immunoassay.Journal of Laboratory Automation,21(3),387-393.
MLA Yao P,et al."Fully Automated Quantification of Insulin Concentration Using a Microfluidic-Based Chemiluminescence Immunoassay".Journal of Laboratory Automation 21.3(2016):387-393.
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