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题名: Imaging and mapping individual target proteins on clinical lymphoma cells by AFM
作者: Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超); Wang WX(王文学)
作者部门: 机器人学研究室
会议名称: 9th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2015
会议日期: November 15-18, 2015
会议地点: Honolulu, HI, USA
会议主办者: Huawei Technologies Co., Ltd.; IEEE Nanotechnology Council; RSC Advances of the Royal Society of Chemistry; Shenzhen Academy of Robotics; University of Arkansas; University of California at Santa Cruz
会议录: 9th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2015
会议录出版者: IEEE Computer Society
会议录出版地: Washington, DC
出版日期: 2015
页码: 84-87
收录类别: EI
ISSN号: 2159-6964
ISBN号: 9781467396714
摘要: The wide applications of atomic force microscopy (AFM) in the past decade have contributed much to the field of cell biology, providing a lot of novel insights into cellular behaviors at the nanoscale. However, current AFM studies are commonly performed on cell lines cultured in vitro which are quite different from the cells in the human body. Directly investigating the physiological activities on tumor cells from clinical patients is of great significance for helping us to better understand the actual cellular activities taking place in the clinical environment. Under the fluorescence recognition of specific tumor cell surface marker, we have used AFM to investigate the binding affinity and nanoscale distributions of CD20 target protein directly on tumor cells prepared from the bone marrow of lymphoma patients. The results provide a new idea to develop closer links between laboratory study and clinical practice, which may have potential impacts on diverse fields such as drug evaluation and efficacy prediction.
语种: 英语
产权排序: 1
内容类型: 会议论文
URI标识: http://ir.sia.cn/handle/173321/18756
Appears in Collections:机器人学研究室_会议论文

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Recommended Citation:
Li M,Liu LQ,Xi N,et al. Imaging and mapping individual target proteins on clinical lymphoma cells by AFM[C]. 见:9th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2015. Honolulu, HI, USA. November 15-18, 2015.
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