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A novel approach for extracting viscoelastic parameters of living cells through combination of inverse finite element simulation and Atomic Force Microscopy
Wei FN(魏发南); Yang, Haitao; Liu LQ(刘连庆); Li GY(李广勇)
作者部门机器人学研究室
关键词Viscoelasticity Atomic Force Microscopy Finite Element Simulation
发表期刊Computer Methods in Biomechanics and Biomedical Engineering
ISSN1025-5842
2017
卷号20期号:4页码:373–384
收录类别SCI ; EI
EI收录号20163802811471
WOS记录号WOS:000395117200004
产权排序1
资助机构National Natural Science Foundation of China (NSFC) [project numbers 61327014 and 61175103].
摘要Dynamic mechanical behaviour of living cells has been described by viscoelasticity. However, quantitation of the viscoelastic parameters for living cells is far from sophisticated. In this paper, combining inverse finite element (FE) simulation with Atomic Force Microscope characterization, we attempt to develop a new method to evaluate and acquire trustworthy viscoelastic index of living cells. First, influence of the experiment parameters on stress relaxation process is assessed using FE simulation. As suggested by the simulations, cell height has negligible impact on shape of the force–time curve, i.e. the characteristic relaxation time; and the effect originates from substrate can be totally eliminated when stiff substrate (Young’s modulus larger than 3 GPa) is used. Then, so as to develop an effective optimization strategy for the inverse FE simulation, the parameters sensitivity evaluation is performed for Young’s modulus, Poisson’s ratio, and characteristic relaxation time. With the experiment data obtained through typical stress relaxation measurement, viscoelastic parameters are extracted through the inverse FE simulation by comparing the simulation results and experimental measurements. Finally, reliability of the acquired mechanical parameters is verified with different load experiments performed on the same cell.
语种英语
WOS标题词Science & Technology ; Technology
WOS类目Computer Science, Interdisciplinary Applications ; Engineering, Biomedical
关键词[WOS]DEPTH-SENSING INDENTATION ; ELASTIC-MODULUS ; SOFT-TISSUES ; NANOINDENTATION ; MODEL ; MECHANICS ; AFM
WOS研究方向Computer Science ; Engineering
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/19198
专题机器人学研究室
通讯作者Liu LQ(刘连庆); Li GY(李广勇)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.University of Chinese Academy of Sciences, Beijing, China
3.Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, United States
推荐引用方式
GB/T 7714
Wei FN,Yang, Haitao,Liu LQ,et al. A novel approach for extracting viscoelastic parameters of living cells through combination of inverse finite element simulation and Atomic Force Microscopy[J]. Computer Methods in Biomechanics and Biomedical Engineering,2017,20(4):373–384.
APA Wei FN,Yang, Haitao,Liu LQ,&Li GY.(2017).A novel approach for extracting viscoelastic parameters of living cells through combination of inverse finite element simulation and Atomic Force Microscopy.Computer Methods in Biomechanics and Biomedical Engineering,20(4),373–384.
MLA Wei FN,et al."A novel approach for extracting viscoelastic parameters of living cells through combination of inverse finite element simulation and Atomic Force Microscopy".Computer Methods in Biomechanics and Biomedical Engineering 20.4(2017):373–384.
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