中国科学院沈阳自动化研究所机构知识库
Advanced  
SIA OpenIR  > 机器人学研究室  > 期刊论文
题名: A novel approach for extracting viscoelastic parameters of living cells through combination of inverse finite element simulation and Atomic Force Microscopy
作者: Wei FN(魏发南); Yang, Haitao; Liu LQ(刘连庆); Li GY(李广勇)
作者部门: 机器人学研究室
通讯作者: 刘连庆
关键词: Viscoelasticity ; Atomic Force Microscopy ; finite element simulation
刊名: Computer Methods in Biomechanics and Biomedical Engineering
ISSN号: 1025-5842
出版日期: 2016
页码: 1-12
收录类别: EI
产权排序: 1
项目资助者: National Natural Science Foundation of China (NSFC) [project numbers 61327014 and 61175103].
摘要: Dynamic mechanical behaviour of living cells has been described by viscoelasticity. However, quantitation of the viscoelastic parameters for living cells is far from sophisticated. In this paper, combining inverse finite element (FE) simulation with Atomic Force Microscope characterization, we attempt to develop a new method to evaluate and acquire trustworthy viscoelastic index of living cells. First, influence of the experiment parameters on stress relaxation process is assessed using FE simulation. As suggested by the simulations, cell height has negligible impact on shape of the force–time curve, i.e. the characteristic relaxation time; and the effect originates from substrate can be totally eliminated when stiff substrate (Young’s modulus larger than 3 GPa) is used. Then, so as to develop an effective optimization strategy for the inverse FE simulation, the parameters sensitivity evaluation is performed for Young’s modulus, Poisson’s ratio, and characteristic relaxation time. With the experiment data obtained through typical stress relaxation measurement, viscoelastic parameters are extracted through the inverse FE simulation by comparing the simulation results and experimental measurements. Finally, reliability of the acquired mechanical parameters is verified with different load experiments performed on the same cell.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.sia.cn/handle/173321/19198
Appears in Collections:机器人学研究室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
A novel approach for extracting viscoelastic parameters of living cells through combination of inverse finite element simulation and Atomic Force Microscopy.pdf(2773KB)期刊论文作者接受稿开放获取View Download

Recommended Citation:
Wei FN,Yang, Haitao,Liu LQ,et al. A novel approach for extracting viscoelastic parameters of living cells through combination of inverse finite element simulation and Atomic Force Microscopy[J]. Computer Methods in Biomechanics and Biomedical Engineering,2016:1-12.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[魏发南]'s Articles
[Yang, Haitao]'s Articles
[刘连庆]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[魏发南]‘s Articles
[Yang, Haitao]‘s Articles
[刘连庆]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: A novel approach for extracting viscoelastic parameters of living cells through combination of inverse finite element simulation and Atomic Force Microscopy.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2016  中国科学院沈阳自动化研究所 - Feedback
Powered by CSpace