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Early predictive factors for lower-extremity motor or sensory deficits and surgical results of patients with spinal tuberculosis: A retrospective study of 329 patients
Wang HW(王洪伟); Yang, Xiao; Shi, Ying; Zhou Y(周跃); Li CQ(李长青); Chen Y(陈语); Yu HL(于海龙); Wang Q(王琪); Liu J(刘军); Cheng, Jiwei; Zhao YW(赵忆文); Han JD(韩建达); Xiang LB(项良碧)
Department机器人学研究室
Source PublicationMEDICINE
ISSN0025-7974
2016
Volume95Issue:34Pages:1-7
Indexed BySCI
WOS IDWOS:000384032900030
Contribution Rank5
Funding OrganizationFoundation of the State Key Laboratory of Robotics [2014-O12] ; Medjaden Academy and Research Foundation for Young Scientists [MJR20150013] ; Liaoning Province Doctor Startup Fund [201601196]
KeywordEpidemiology Motor Deficits Predictive Factors Sensory Disturbance Spinal Tuberculosis
Abstract

Many studies about the characteristics of spinal tuberculosis (STB) have been published, but none has investigated the predictive factors for lower-extremity motor or sensory deficits (LMSD) in patients with STB.The objective of this study was to find early predictive factors for LMSD and evaluate surgical results of patients with STB.From 2001 through 2010, 329 patients with STB were treated in our department and surgical treatment was performed in 274 patients. The factors assessed included age, sex, duration of symptoms, worsening of illness, clinical symptoms, clinical signs, imaging characteristics, kyphotic angle, Oswestry disability index (ODI), and visual analogue scale (VAS) scores.Of the 329 patients studied, 164 presented with LMSD (the LMSD group), of which 93 patients (28.3%) had motor deficits and 177 patients (53.8%) had sensory disturbance. The other 165 patients were included in the control group (the No LMSD group). Using univariate logistic regression analysis, we found that the sex (P=0.042), age (P=0.001), worsening of sickness (P=0.013), location (P=0.009), and spinal compression (P=0.035) were the risk factors of LMSD. Furthermore, the multivariate logistic regression analysis indicated that age (OR=1.761, 95% CI: 1.227-2.526, P=0.002), worsening of sickness (yes vs no: OR=1.910, 95% CI: 1.161-3.141, P=0.011), location (T vs C: OR=0.204, 95% CI: 0.063-0.662, P=0.008), and spinal compression (yes vs no: OR=1.672, 95% CI: 1.020-2.741, P=0.042) were independent risk factors of LMSD. Surgical treatment was performed in 274 patients. The kyphotic angle improved from 25.89.1 degrees preoperatively to 14.0 +/- 7.6 degrees, with a mean correction of 11.8 +/- 4.0 degrees, and a mean correction loss of 1.5 +/- 1.8 degrees at final visit. There were significant differences between the preoperative and the final ODI and VAS scores in both groups (P<0.001 and P<0.001, respectively).Spinal tuberculosis with cervical or lumbar vertebra involvement among the elder patients with a history of worsening of illness and spinal compression tended to cause LMSD, such as motor deficits or sensory disturbance. We should implement an appropriate treatment regimen to prevent exacerbation of STB such as operation, which can achieve thoroughness of debridement, adequate spinal stabilization, and better functional recovery.

Language英语
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectMedicine, General & Internal
WOS KeywordKyphotic Deformity ; Potts-disease ; Experience ; Management ; Instrumentation ; Debridement
WOS Research AreaGeneral & Internal Medicine
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/19267
Collection机器人学研究室
Corresponding AuthorWang HW(王洪伟); Xiang LB(项良碧)
Affiliation1.Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA
2.Department of Nursing, People's Liberation Army 463rd Hospital, Shenyang, Liaoning
3.Department of Orthopedics, Xinqiao Hospital, The Third Military Medical University, Chongqing
4.Department of Orthopedics, People's Liberation Army 113th Hospital, Ningbo, Zhejiang
5.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Science, Shenyang, Liaoning, China
Recommended Citation
GB/T 7714
Wang HW,Yang, Xiao,Shi, Ying,et al. Early predictive factors for lower-extremity motor or sensory deficits and surgical results of patients with spinal tuberculosis: A retrospective study of 329 patients[J]. MEDICINE,2016,95(34):1-7.
APA Wang HW.,Yang, Xiao.,Shi, Ying.,Zhou Y.,Li CQ.,...&Xiang LB.(2016).Early predictive factors for lower-extremity motor or sensory deficits and surgical results of patients with spinal tuberculosis: A retrospective study of 329 patients.MEDICINE,95(34),1-7.
MLA Wang HW,et al."Early predictive factors for lower-extremity motor or sensory deficits and surgical results of patients with spinal tuberculosis: A retrospective study of 329 patients".MEDICINE 95.34(2016):1-7.
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