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Nanoscale quantifying the effects of targeted drug on chemotherapy in lymphoma treatment using atomic force microscopy
作者: Li M(李密); Xiao XB(肖秀斌); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
作者部门: 机器人学研究室
通讯作者: 刘连庆
关键词: Atomic force microscopy (AFM) ; cancer, drug ; mechanical properties ; surface roughness
刊名: IEEE Transactions on Biomedical Engineering
ISSN号: 0018-9294
出版日期: 2016
卷号: 63, 期号:10, 页码:2187-2199
收录类别: SCI ; EI
产权排序: 1
项目资助者: National Natural Science Foundation of China (61503372, 61522312, 61175103, 61375107, 61327014, and 61433017), the Research Fund of the State Key Laboratory of Robotics (No. 2014-Z07), and the CAS FEA International Partnership Program for Creative Research Teams.
摘要: The applications of targeted drugs in treating cancers have significantly improved the survival rates of patients. However, in the clinical practice, targeted drugs are commonly combined with chemotherapy drugs, causing that the exact contribution of targeted drugs to the clinical outcome is difficult to evaluate. Quantitatively investigating the effects of targeted drugs on chemotherapy drugs on cancer cells is useful for us to understand drug actions and design better drugs. The advent of atomic force microscopy (AFM) provides a powerful tool for probing the nanoscale physiological activities of single live cells. In this paper, the detailed changes in cell morphology and mechanical properties were quantified on single lymphoma cells during the actions of rituximab (a monoclonal antibody targeted drug) and two chemotherapy drugs (cisplatin and cytarabine) by AFM. AFM imaging revealed the distinct changes of cellular ultramicro structures induced by the drugs. The changes of cellular mechanical properties after the drug stimulations were measured by AFM indenting. The statistical histograms of cellular surface roughness and mechanical properties quantitatively showed that rituximab could remarkably strengthen the killing effects of chemotherapy drugs. The study offers a new way to quantify the synergistic interactions between targeted drugs and chemotherapy drugs at the nanoscale, which will have potential impacts on predicting the efficacies of drug combinations before clinical treatments.
语种: 英语
EI收录号: 20164202905112
WOS记录号: WOS:000384570200022
WOS标题词: Science & Technology ; Technology
类目[WOS]: Engineering, Biomedical
关键词[WOS]: ACUTE MYELOID-LEUKEMIA ; NON-HODGKINS-LYMPHOMA ; CANCER-CELLS ; LIVING CELLS ; MONOCLONAL-ANTIBODIES ; CISPLATIN RESISTANCE ; BREAST-CANCER ; MYOSIN-II ; RITUXIMAB ; AFM
研究领域[WOS]: Engineering
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内容类型: 期刊论文
URI标识: http://ir.sia.cn/handle/173321/19269
Appears in Collections:机器人学研究室_期刊论文

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Recommended Citation:
Li M,Xiao XB,Liu LQ,et al. Nanoscale quantifying the effects of targeted drug on chemotherapy in lymphoma treatment using atomic force microscopy[J]. IEEE Transactions on Biomedical Engineering,2016,63(10):2187-2199.
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