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Nanoscale quantifying the effects of targeted drug on chemotherapy in lymphoma treatment using atomic force microscopy
Li M(李密); Xiao XB(肖秀斌); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
Department机器人学研究室
Source PublicationIEEE Transactions on Biomedical Engineering
ISSN0018-9294
2016
Volume63Issue:10Pages:2187-2199
Indexed BySCI ; EI
EI Accession number20164202905112
WOS IDWOS:000384570200022
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China (61503372, 61522312, 61175103, 61375107, 61327014, and 61433017), the Research Fund of the State Key Laboratory of Robotics (No. 2014-Z07), and the CAS FEA International Partnership Program for Creative Research Teams.
KeywordAtomic Force Microscopy (Afm) Mechanical Properties Cancer Surface Roughness Drug
AbstractThe applications of targeted drugs in treating cancers have significantly improved the survival rates of patients. However, in the clinical practice, targeted drugs are commonly combined with chemotherapy drugs, causing that the exact contribution of targeted drugs to the clinical outcome is difficult to evaluate. Quantitatively investigating the effects of targeted drugs on chemotherapy drugs on cancer cells is useful for us to understand drug actions and design better drugs. The advent of atomic force microscopy (AFM) provides a powerful tool for probing the nanoscale physiological activities of single live cells. In this paper, the detailed changes in cell morphology and mechanical properties were quantified on single lymphoma cells during the actions of rituximab (a monoclonal antibody targeted drug) and two chemotherapy drugs (cisplatin and cytarabine) by AFM. AFM imaging revealed the distinct changes of cellular ultramicro structures induced by the drugs. The changes of cellular mechanical properties after the drug stimulations were measured by AFM indenting. The statistical histograms of cellular surface roughness and mechanical properties quantitatively showed that rituximab could remarkably strengthen the killing effects of chemotherapy drugs. The study offers a new way to quantify the synergistic interactions between targeted drugs and chemotherapy drugs at the nanoscale, which will have potential impacts on predicting the efficacies of drug combinations before clinical treatments.
Language英语
WOS HeadingsScience & Technology ; Technology
WOS SubjectEngineering, Biomedical
WOS KeywordACUTE MYELOID-LEUKEMIA ; NON-HODGKINS-LYMPHOMA ; CANCER-CELLS ; LIVING CELLS ; MONOCLONAL-ANTIBODIES ; CISPLATIN RESISTANCE ; BREAST-CANCER ; MYOSIN-II ; RITUXIMAB ; AFM
WOS Research AreaEngineering
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/19269
Collection机器人学研究室
Corresponding AuthorLiu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, China
3.Department of Electrical and Computer Engineering, Michigan State University, United States
Recommended Citation
GB/T 7714
Li M,Xiao XB,Liu LQ,et al. Nanoscale quantifying the effects of targeted drug on chemotherapy in lymphoma treatment using atomic force microscopy[J]. IEEE Transactions on Biomedical Engineering,2016,63(10):2187-2199.
APA Li M,Xiao XB,Liu LQ,Xi N,&Wang YC.(2016).Nanoscale quantifying the effects of targeted drug on chemotherapy in lymphoma treatment using atomic force microscopy.IEEE Transactions on Biomedical Engineering,63(10),2187-2199.
MLA Li M,et al."Nanoscale quantifying the effects of targeted drug on chemotherapy in lymphoma treatment using atomic force microscopy".IEEE Transactions on Biomedical Engineering 63.10(2016):2187-2199.
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