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Facile modulation of cell adhesion to a poly(ethylene glycol) diacrylate film with incorporation of polystyrene nano-spheres
Yang WG(杨文广); Yu HB(于海波); Li GX(李恭新); Wang YC(王越超); Liu LQ(刘连庆)
作者部门机器人学研究室
关键词Pegda Cell Adhesion Nano Composites Mechanical Properties Bioengineering
发表期刊Biomedical Microdevices
ISSN1387-2176
2016
卷号18期号:6页码:1-9
收录类别SCI ; EI
EI收录号20164603021169
WOS记录号WOS:000391424600011
产权排序1
资助机构National Natural Science Foundation of China (Project No. 61302003, 61475183 and 61503258), the NSFC/RGC Joint Research Scheme (Project No. 51461165501) and the CAS FEA International Partnership Program for Creative Research Teams and the Instrument Developing Project of the Chinese Academy of Sciences (Grant No. yz201339).
摘要Poly(ethylene glycol) diacrylate (PEGDA) is a common hydrogel that has been actively investigated for various tissue engineering applications owing to its biocompatibility and excellent mechanical properties. However, the native PEGDA films are known for their bio-inertness which can hinder cell adhesion, thereby limiting their applications in tissue engineering and biomedicine. Recently, nano composite technology has become a particularly hot topic, and has led to the development of new methods for delivering desired properties to nanomaterials. In this study, we added polystyrene nano-spheres (PS) into a PEGDA solution to synthesize a nano-composite film and evaluated its characteristics. The experimental results showed that addition of the nanospheres to the PEGDA film not only resulted in modification of the mechanical properties and surface morphology but further improved the adhesion of cells on the film. The tensile modulus showed clear dependence on the addition of PS, which enhanced the mechanical properties of the PEGDA-PS film. We attribute the high stiffness of the hybrid hydrogel to the formation of additional cross-links between polymeric chains and the nano-sphere surface in the network. The effect of PS on cell adhesion and proliferation was evaluated in L929 mouse fibroblast cells that were seeded on the surface of various PEGDA-PS films. Cells density increased with a larger PS concentration, and the cells displayed a spreading morphology on the hybrid films, which promoted cell proliferation. Impressively, cellular stiffness could also be modulated simply by tuning the concentration of nano-spheres. Our results indicate that the addition of PS can effectively tailor the physical and biological properties of PEGDA as well as the mechanical properties of cells, with benefits for biomedical and biotechnological applications.
语种英语
WOS标题词Science & Technology ; Technology
WOS类目Engineering, Biomedical ; Nanoscience & Nanotechnology
关键词[WOS]NANOCOMPOSITE HYDROGELS ; MECHANICAL-PROPERTIES ; SILVER NANOPARTICLES ; MICROENVIRONMENT ; DIFFERENTIATION
WOS研究方向Engineering ; Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/19418
专题机器人学研究室
通讯作者Yu HB(于海波); Liu LQ(刘连庆)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.University of Chinese Academy of Sciences, Beijing, China
推荐引用方式
GB/T 7714
Yang WG,Yu HB,Li GX,et al. Facile modulation of cell adhesion to a poly(ethylene glycol) diacrylate film with incorporation of polystyrene nano-spheres[J]. Biomedical Microdevices,2016,18(6):1-9.
APA Yang WG,Yu HB,Li GX,Wang YC,&Liu LQ.(2016).Facile modulation of cell adhesion to a poly(ethylene glycol) diacrylate film with incorporation of polystyrene nano-spheres.Biomedical Microdevices,18(6),1-9.
MLA Yang WG,et al."Facile modulation of cell adhesion to a poly(ethylene glycol) diacrylate film with incorporation of polystyrene nano-spheres".Biomedical Microdevices 18.6(2016):1-9.
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