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Processing, characterization and hemostatic mechanism of a ultraporous collagen/ORC biodegradable composite with excellent biological effectiveness
Cheng WL(程玮璐); Li H(李慧); Zheng XF(郑雄飞); Chen, Lei; Cheng F(程凤); He JM(贺金梅); Liu, Ke; Cai, Panpan; Wang XF(王晓峰); Huang YD(黄玉东)
作者部门机器人学研究室
发表期刊PHYSICAL CHEMISTRY CHEMICAL PHYSICS
ISSN1463-9076
2016
卷号18期号:42页码:29183-29191
收录类别SCI
WOS记录号WOS:000387024300019
产权排序3
资助机构State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University [LK1510] ; National Natural Science Foundation of China [51305438] ; National Key R&D Program of China (Biomedical material R&D and tissue repair replacement) [2016YFC1101700]
摘要Collagen, one of the most biocompatible materials in nature, is widely used in wound healing and organ repair. However, the limited mechanical strength and biological effectiveness of collagen restrain its application as a hemostasis and filling material in medicine. To overcome these limitations, ultraporous collagen/oxidized regenerated cellulose (Col/ORC) composites were prepared. The results showed that the Col-0.25% ORC composite had optimal wettability, porosity, and water absorption. An MTT assay proved that the Col and Col/ORC composites possessed no cytotoxicity in living cells. Evaluation of the hemostatic time in vivo and the amount of bleeding in two injury models revealed that the Col-0.25% ORC composite has the most outstanding biological effectiveness and could be biodegraded completely without any inflammatory reaction after 3 weeks. The SEM micrographs showed that the fasciculate ORC fibers were evenly dispersed into the reticulate structure of the Col sponge. The FT-IR spectra of the Col-ORC composites were completely different from that of neat ORC, but similar to Col spectra. Moreover, a possible hemostasis mechanism was discussed based on ELISA analysis, coagulation function, and physicochemical properties.
语种英语
WOS标题词Science & Technology ; Physical Sciences
WOS类目Chemistry, Physical ; Physics, Atomic, Molecular & Chemical
关键词[WOS]OXIDIZED REGENERATED CELLULOSE ; IONIC LIQUID ; WOUND REPAIR ; GELATIN ; SURFACE ; FIBERS ; AGENTS ; BLOOD ; DRUG ; FILM
WOS研究方向Chemistry ; Physics
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/19429
专题机器人学研究室
通讯作者Wang XF(王晓峰); Huang YD(黄玉东)
作者单位1.State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai, China
2.School of Chemistry and Chemical Engineering, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China
3.Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China
4.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
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GB/T 7714
Cheng WL,Li H,Zheng XF,et al. Processing, characterization and hemostatic mechanism of a ultraporous collagen/ORC biodegradable composite with excellent biological effectiveness[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2016,18(42):29183-29191.
APA Cheng WL.,Li H.,Zheng XF.,Chen, Lei.,Cheng F.,...&Huang YD.(2016).Processing, characterization and hemostatic mechanism of a ultraporous collagen/ORC biodegradable composite with excellent biological effectiveness.PHYSICAL CHEMISTRY CHEMICAL PHYSICS,18(42),29183-29191.
MLA Cheng WL,et al."Processing, characterization and hemostatic mechanism of a ultraporous collagen/ORC biodegradable composite with excellent biological effectiveness".PHYSICAL CHEMISTRY CHEMICAL PHYSICS 18.42(2016):29183-29191.
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