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Poroelasticity of cell nuclei revealed through atomic force microscopy characterization
Wei FN(魏发南); Lan, Fei; Liu B(刘斌); Liu LQ(刘连庆); Li GY(李广勇)
Source PublicationApplied Physics Letters
Indexed BySCI ; EI
EI Accession number20164903086537
WOS IDWOS:000388834200031
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China (NSFC Project Nos. 61327014, 61433017 and, 61522312).
AbstractWith great potential in precision medical application, cell biomechanics is rising as a hot topic in biology. Cell nucleus, as the largest component within cell, not only contributes greatly to the cell's mechanical behavior, but also serves as the most vital component within cell. However, cell nucleus' mechanics is still far from unambiguous up to now. In this paper, we attempted to characterize and evaluate the mechanical property of isolated cell nuclei using Atomic Force Microscopy with a tipless probe. As indicated from typical indentation, changing loading rate and stress relaxation experiment results, cell nuclei showed significant dynamically mechanical property, i.e., time-dependent mechanics. Furthermore, through theoretical analysis, finite element simulation and stress relaxation experiment, the nature of nucleus' mechanics was better described by poroelasticity, rather than viscoelasticity. Therefore, the essence of nucleus' mechanics was clarified to be poroelastic through a sophisticated analysis. Finally, we estimated the poroelastic parameters for nuclei of two types of cells through a combination of experimental data and finite element simulation.
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectPhysics, Applied
WOS Research AreaPhysics
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLiu LQ(刘连庆); Li GY(李广勇)
Affiliation1.School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, 350116, China
2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
3.University of Chinese Academy of Sciences, Beijing 100049, China
4.Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States
Recommended Citation
GB/T 7714
Wei FN,Lan, Fei,Liu B,et al. Poroelasticity of cell nuclei revealed through atomic force microscopy characterization[J]. Applied Physics Letters,2016,109(21):1-5.
APA Wei FN,Lan, Fei,Liu B,Liu LQ,&Li GY.(2016).Poroelasticity of cell nuclei revealed through atomic force microscopy characterization.Applied Physics Letters,109(21),1-5.
MLA Wei FN,et al."Poroelasticity of cell nuclei revealed through atomic force microscopy characterization".Applied Physics Letters 109.21(2016):1-5.
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