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Poroelasticity of cell nuclei revealed through atomic force microscopy characterization
Wei FN(魏发南); Lan, Fei; Liu B(刘斌); Liu LQ(刘连庆); Li GY(李广勇)
作者部门机器人学研究室
发表期刊Applied Physics Letters
ISSN0003-6951
2016
卷号109期号:21页码:1-5
收录类别SCI ; EI
EI收录号20164903086537
WOS记录号WOS:000388834200031
产权排序1
资助机构National Natural Science Foundation of China (NSFC Project Nos. 61327014, 61433017 and, 61522312).
摘要With great potential in precision medical application, cell biomechanics is rising as a hot topic in biology. Cell nucleus, as the largest component within cell, not only contributes greatly to the cell's mechanical behavior, but also serves as the most vital component within cell. However, cell nucleus' mechanics is still far from unambiguous up to now. In this paper, we attempted to characterize and evaluate the mechanical property of isolated cell nuclei using Atomic Force Microscopy with a tipless probe. As indicated from typical indentation, changing loading rate and stress relaxation experiment results, cell nuclei showed significant dynamically mechanical property, i.e., time-dependent mechanics. Furthermore, through theoretical analysis, finite element simulation and stress relaxation experiment, the nature of nucleus' mechanics was better described by poroelasticity, rather than viscoelasticity. Therefore, the essence of nucleus' mechanics was clarified to be poroelastic through a sophisticated analysis. Finally, we estimated the poroelastic parameters for nuclei of two types of cells through a combination of experimental data and finite element simulation.
语种英语
WOS标题词Science & Technology ; Physical Sciences
WOS类目Physics, Applied
关键词[WOS]POWER-LAW RHEOLOGY ; MECHANICAL-PROPERTIES ; VISCOELASTIC PROPERTIES ; DEFORMATION ; INDENTATION ; NANOSCALE
WOS研究方向Physics
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/19477
专题机器人学研究室
通讯作者Liu LQ(刘连庆); Li GY(李广勇)
作者单位1.School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, 350116, China
2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
3.University of Chinese Academy of Sciences, Beijing 100049, China
4.Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States
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GB/T 7714
Wei FN,Lan, Fei,Liu B,et al. Poroelasticity of cell nuclei revealed through atomic force microscopy characterization[J]. Applied Physics Letters,2016,109(21):1-5.
APA Wei FN,Lan, Fei,Liu B,Liu LQ,&Li GY.(2016).Poroelasticity of cell nuclei revealed through atomic force microscopy characterization.Applied Physics Letters,109(21),1-5.
MLA Wei FN,et al."Poroelasticity of cell nuclei revealed through atomic force microscopy characterization".Applied Physics Letters 109.21(2016):1-5.
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