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BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting
Huang J(黄洁); Fu H(付寒); Wang ZY(王芷莹); Meng QY(孟庆圆); Liu SM(刘素梅); Wang HR(王赫然); Zheng XF(郑雄飞); Dai JW(戴建武); Zhang ZJ(张智军)
作者部门机器人学研究室
发表期刊RSC Advances
ISSN2046-2069
2016
卷号6期号:110页码:108423-108430
收录类别SCI ; EI
EI收录号20164803073217
WOS记录号WOS:000389342800036
产权排序3
资助机构Key Research Program of the Chinese Academy of Sciences (No. ZDRW-ZS-2016-2-3), the Ministry of Science and Technology of China (No. 2014CB965003, 2016YFC1000809).
摘要Three-dimensional (3D) bioprinting technology offers the possibility to deliver, in a defined and organized manner, scaffolding materials and living cells, and therefore holds much promise for tissue engineering and regenerative medicine. In this work, we explored the possibility of gelatin/sodium alginate/carboxymethyl chitosan (Gel/SA/CMCS) hydrogel combining with bone mesenchymal stem cells (BMSCs) for 3D bioprinting. Compared to the commonly used 3D bioprinting materials such as gelatin/sodium alginate (Gel/SA) hydrogel, the Gel/SA/CMCS hydrogel we developed shows excellent equilibrium water content, good mechanical properties, antibacterial activity, and a slow degradation rate. With this kind of material, we generated a scaffold with homogenous cell distribution. Cell viability after 3D printing showed that over 85% of the printed cells were viable at 0 and 2 days of culturing. Our work demonstrates the feasibility of mixing Gel/SA/CMCS hydrogel with stem cells for 3D bioprinting.
语种英语
WOS标题词Science & Technology ; Physical Sciences
WOS类目Chemistry, Multidisciplinary
关键词[WOS]MESENCHYMAL STEM-CELLS ; ENGINEERED CARTILAGE CONSTRUCTS ; OSTEOGENIC DIFFERENTIATION ; VALVE CONDUITS ; TISSUE ; ALGINATE ; ORGANIZATION ; FABRICATION ; SCAFFOLDS ; CULTURE
WOS研究方向Chemistry
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文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/19478
专题机器人学研究室
通讯作者Dai JW(戴建武); Zhang ZJ(张智军)
作者单位1.Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, CAS Center for Excellence in Nanoscience, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, Jiangsu, 215123, China
2.State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100190, China
3.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
4.University of Chinese Academy of Sciences, 19(A) Yuquan Road, Beijing, 100039, China
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GB/T 7714
Huang J,Fu H,Wang ZY,et al. BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting[J]. RSC Advances,2016,6(110):108423-108430.
APA Huang J.,Fu H.,Wang ZY.,Meng QY.,Liu SM.,...&Zhang ZJ.(2016).BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting.RSC Advances,6(110),108423-108430.
MLA Huang J,et al."BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting".RSC Advances 6.110(2016):108423-108430.
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