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AFM Measurement of the Mechanical Properties of Single Adherent Cells Based on Vibration
Zhang C(张闯); Shi JL(施佳林); Wang WX(王文学); Xi N(席宁); Wang YC(王越超); Liu LQ(刘连庆)
作者部门机器人学研究室
会议名称2016 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)
会议日期October 9-14, 2016
会议地点Daejeon, Korea
会议录名称2016 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)
出版者IEEE
出版地New York
2016
页码5205-5209
收录类别EI ; CPCI(ISTP)
EI收录号20165203162162
WOS记录号WOS:000391921705036
产权排序1
ISBN号978-1-5090-3763-6
摘要

Cellular mechanical properties as the main physical performance characteristics have been actively studied in the past years for the study of cytobiology and the development of medicine. In this study, by combining Hertz model, a novel strategy is proposed to simultaneously measure the cellular mechanical properties including cellular mass, elasticity and viscosity, based on the principle of forced vibration stimulated by simple harmonic force, with piezoelectric transducer (PZT) as vibrator and Atomic Force Microscope (AFM) as detector. The corresponding theoretical model was derived and the simulation was realized based on the proposed model. The experiments of indentations and vibrations with myoblasts and myotubes were implemented to calculate the three mechanical parameters of cells according to the proposed strategy. The results validated the proposed approach. This work would be useful for the development of cytology, medicine, previously diagnose, specific therapy and so on.

语种英语
引用统计
文献类型会议论文
条目标识符http://ir.sia.cn/handle/173321/19562
专题机器人学研究室
通讯作者Wang WX(王文学); Liu LQ(刘连庆)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Science, Shenyang, 10016, China
2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China
3.University of Chinese Academy of Sciences, Beijing, 100049, China
4.Emerging Technologies Institute, Department of Industrial and Manufacturing Systems Engineering, University of Hong Kong, Pokfulam, Hong Kong
推荐引用方式
GB/T 7714
Zhang C,Shi JL,Wang WX,et al. AFM Measurement of the Mechanical Properties of Single Adherent Cells Based on Vibration[C]. New York:IEEE,2016:5205-5209.
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