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AFM Measurement of the Mechanical Properties of Single Adherent Cells Based on Vibration
Zhang C(张闯); Shi JL(施佳林); Wang WX(王文学); Xi N(席宁); Wang YC(王越超); Liu LQ(刘连庆)
Department机器人学研究室
Conference Name2016 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)
Conference DateOctober 9-14, 2016
Conference PlaceDaejeon, Korea
Source Publication2016 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)
PublisherIEEE
Publication PlaceNew York
2016
Pages5205-5209
Indexed ByEI ; CPCI(ISTP)
EI Accession number20165203162162
WOS IDWOS:000391921705036
Contribution Rank1
ISBN978-1-5090-3763-6
Abstract

Cellular mechanical properties as the main physical performance characteristics have been actively studied in the past years for the study of cytobiology and the development of medicine. In this study, by combining Hertz model, a novel strategy is proposed to simultaneously measure the cellular mechanical properties including cellular mass, elasticity and viscosity, based on the principle of forced vibration stimulated by simple harmonic force, with piezoelectric transducer (PZT) as vibrator and Atomic Force Microscope (AFM) as detector. The corresponding theoretical model was derived and the simulation was realized based on the proposed model. The experiments of indentations and vibrations with myoblasts and myotubes were implemented to calculate the three mechanical parameters of cells according to the proposed strategy. The results validated the proposed approach. This work would be useful for the development of cytology, medicine, previously diagnose, specific therapy and so on.

Language英语
Citation statistics
Document Type会议论文
Identifierhttp://ir.sia.cn/handle/173321/19562
Collection机器人学研究室
Corresponding AuthorWang WX(王文学); Liu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Science, Shenyang, 10016, China
2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China
3.University of Chinese Academy of Sciences, Beijing, 100049, China
4.Emerging Technologies Institute, Department of Industrial and Manufacturing Systems Engineering, University of Hong Kong, Pokfulam, Hong Kong
Recommended Citation
GB/T 7714
Zhang C,Shi JL,Wang WX,et al. AFM Measurement of the Mechanical Properties of Single Adherent Cells Based on Vibration[C]. New York:IEEE,2016:5205-5209.
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