SIA OpenIR  > 机器人学研究室
Alternative TitleCell physiological information detection system and detection method
刘连庆; 于鹏; 张常麟; 李鹏; 李广勇
Rights Holder中国科学院沈阳自动化研究所
Patent Agent沈阳科苑专利商标代理有限公司 21002
Other AbstractThe invention relates to a cell physiological information detection system and detection method based on planar patch clamp technique and robotization probe control technology. The cell physiological information detection system includes a planar patch clamp module and a nano manipulation robot module which are in connection; the planar patch clamp module is used for cell adsorption, sealing and membrane breaking; and the nano manipulation robot module is used to achieve nano observation and nano manipulation of cells. The cell physiological information detection method is as follows: a macro micro motion platform and a Z-direction nano scanner are controlled to drive a probe to achieve nanometer level displacement; a laser deflection signal is detected by a photoelectric sensor, and then fed back to a data processing and human-computer interaction interface to obtain probe contact force, and ion current synchronous detection can be achieved by an electrode and a signal amplifier. The cell physiological information detection system uses a scanning probe to apply pico-Newton to nano-Newton level supermicro mechanical force stimulation to the cell surface, and at the same time, uses the planar patch clamp to realize detection of currents of mechanically gated ion channels of cells.
PCT Attributes
Application Date2013-08-22
Date Available2016-12-28
Application NumberCN201310374751.5
Open (Notice) NumberCN104419642B
Contribution Rank1
Document Type专利
Recommended Citation
GB/T 7714
刘连庆,于鹏,张常麟,等. 一种细胞生理信息检测系统及其检测方法[P]. 2015-03-18.
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