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High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues
Yang WG(杨文广); Yu HB(于海波); Wang YC(王越超); Liu LQ(刘连庆)
作者部门机器人学研究室
发表期刊Small
ISSN1613-6810
2017
卷号13期号:5页码:1-11
收录类别SCI ; EI
EI收录号20170603328219
WOS记录号WOS:000397009300010
产权排序1
资助机构National Natural Science Foundation of China (Project Nos. 61302003, 61475183, and 61522312), the NSFC/RGC Joint Research Scheme (Project No. 51461165501), and the CAS FEA International Partnership Program for Creative Research Teams.
摘要3D hydrogel microstructures that encapsulate cells have been used in broad applications in microscale tissue engineering, personalized drug screening, and regenerative medicine. Recent technological advances in microstructure assembly, such as bioprinting, magnetic assembly, microfluidics, and acoustics, have enabled the construction of designed 3D tissue structures with spatially organized cells in vitro. However, a bottleneck exists that still hampers the application of microtissue structures, due to a lack of techniques that combined high-throughput fabrication and flexible assembly. Here, a versatile method for fabricating customized microstructures and reorganizing building blocks composed of functional components into a combined single geometric shape is demonstrated. The arbitrary microstructures are dynamically synthesized in a microfluidic device and then transferred to an optically induced electrokinetics chip for manipulation and assembly. Moreover, building blocks containing different cells can be arranged into a desired geometry with specific shape and size, which can be used for microscale tissue engineering.
语种英语
WOS标题词Science & Technology ; Physical Sciences ; Technology
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
关键词[WOS]STOP-FLOW LITHOGRAPHY ; DIELECTROPHORETIC ODEP FORCE ; OPTOELECTRONIC TWEEZERS ; 2-PHOTON POLYMERIZATION ; MICROFLUIDIC PLATFORM ; PRINTING TECHNOLOGY ; DRUG-DELIVERY ; STEM-CELLS ; HYDROGELS ; MICROPARTICLES
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/19887
专题机器人学研究室
通讯作者Yu HB(于海波); Liu LQ(刘连庆)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110000, China
2.University of Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式
GB/T 7714
Yang WG,Yu HB,Wang YC,et al. High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues[J]. Small,2017,13(5):1-11.
APA Yang WG,Yu HB,Wang YC,&Liu LQ.(2017).High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues.Small,13(5),1-11.
MLA Yang WG,et al."High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues".Small 13.5(2017):1-11.
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