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Imaging and force recognition of single molecular behaviors using atomic force microscopy
Li M(李密); Dang D(党丹); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
作者部门机器人学研究室
关键词Atomic Force Microscopy Single-molecule Topography Mechanics Molecular Recognition
发表期刊Sensors (Switzerland)
ISSN1424-8220
2017
卷号17期号:1页码:1-20
收录类别SCI ; EI
EI收录号20170503301801
WOS记录号WOS:000393021000199
产权排序1
资助机构National Natural Science Foundation of China (61503372, 61522312, 61327014, 61433017), the Youth Innovation Promotion Association CAS (No. 2017243), and the CAS FEA International Partnership Program for Creative Research Teams.
摘要The advent of atomic force microscopy (AFM) has provided a powerful tool for investigating the behaviors of single native biological molecules under physiological conditions. AFM can not only image the conformational changes of single biological molecules at work with sub-nanometer resolution, but also sense the specific interactions of individual molecular pair with piconewton force sensitivity. In the past decade, the performance of AFM has been greatly improved, which makes it widely used in biology to address diverse biomedical issues. Characterizing the behaviors of single molecules by AFM provides considerable novel insights into the underlying mechanisms guiding life activities, contributing much to cell and molecular biology. In this article, we review the recent developments of AFM studies in single-molecule assay. The related techniques involved in AFM single-molecule assay were firstly presented, and then the progress in several aspects (including molecular imaging, molecular mechanics, molecular recognition, and molecular activities on cell surface) was summarized. The challenges and future directions were also discussed.
语种英语
WOS标题词Science & Technology ; Physical Sciences ; Technology
WOS类目Chemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
关键词[WOS]HIGH-SPEED AFM ; DYNAMIC BIOMOLECULAR PROCESSES ; MEMBRANE-PROTEINS ; CELL-SURFACE ; LIVING CELLS ; CANCER-CELLS ; IN-VIVO ; BIOPHYSICAL PROPERTIES ; MECHANICAL-PROPERTIES ; FUNCTIONAL-ANALYSIS
WOS研究方向Chemistry ; Electrochemistry ; Instruments & Instrumentation
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文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/19888
专题机器人学研究室
通讯作者Liu LQ(刘连庆); Xi N(席宁)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.School of Medical Device, Shenyang Pharmaceutical University, Shenyang 110016, China
3.Department of Industrial and Manufacturing Systems Engineering, The University of Hong Kong, Hong Kong
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GB/T 7714
Li M,Dang D,Liu LQ,et al. Imaging and force recognition of single molecular behaviors using atomic force microscopy[J]. Sensors (Switzerland),2017,17(1):1-20.
APA Li M,Dang D,Liu LQ,Xi N,&Wang YC.(2017).Imaging and force recognition of single molecular behaviors using atomic force microscopy.Sensors (Switzerland),17(1),1-20.
MLA Li M,et al."Imaging and force recognition of single molecular behaviors using atomic force microscopy".Sensors (Switzerland) 17.1(2017):1-20.
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