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Imaging and force recognition of single molecular behaviors using atomic force microscopy
Li M(李密); Dang D(党丹); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
Department机器人学研究室
Source PublicationSensors (Switzerland)
ISSN1424-8220
2017
Volume17Issue:1Pages:1-20
Indexed BySCI ; EI
EI Accession number20170503301801
WOS IDWOS:000393021000199
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China (61503372, 61522312, 61327014, 61433017), the Youth Innovation Promotion Association CAS (No. 2017243), and the CAS FEA International Partnership Program for Creative Research Teams.
KeywordAtomic Force Microscopy Single-molecule Topography Mechanics Molecular Recognition
AbstractThe advent of atomic force microscopy (AFM) has provided a powerful tool for investigating the behaviors of single native biological molecules under physiological conditions. AFM can not only image the conformational changes of single biological molecules at work with sub-nanometer resolution, but also sense the specific interactions of individual molecular pair with piconewton force sensitivity. In the past decade, the performance of AFM has been greatly improved, which makes it widely used in biology to address diverse biomedical issues. Characterizing the behaviors of single molecules by AFM provides considerable novel insights into the underlying mechanisms guiding life activities, contributing much to cell and molecular biology. In this article, we review the recent developments of AFM studies in single-molecule assay. The related techniques involved in AFM single-molecule assay were firstly presented, and then the progress in several aspects (including molecular imaging, molecular mechanics, molecular recognition, and molecular activities on cell surface) was summarized. The challenges and future directions were also discussed.
Language英语
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
WOS SubjectChemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS KeywordHIGH-SPEED AFM ; DYNAMIC BIOMOLECULAR PROCESSES ; MEMBRANE-PROTEINS ; CELL-SURFACE ; LIVING CELLS ; CANCER-CELLS ; IN-VIVO ; BIOPHYSICAL PROPERTIES ; MECHANICAL-PROPERTIES ; FUNCTIONAL-ANALYSIS
WOS Research AreaChemistry ; Electrochemistry ; Instruments & Instrumentation
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Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/19888
Collection机器人学研究室
Corresponding AuthorLiu LQ(刘连庆); Xi N(席宁)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.School of Medical Device, Shenyang Pharmaceutical University, Shenyang 110016, China
3.Department of Industrial and Manufacturing Systems Engineering, The University of Hong Kong, Hong Kong
Recommended Citation
GB/T 7714
Li M,Dang D,Liu LQ,et al. Imaging and force recognition of single molecular behaviors using atomic force microscopy[J]. Sensors (Switzerland),2017,17(1):1-20.
APA Li M,Dang D,Liu LQ,Xi N,&Wang YC.(2017).Imaging and force recognition of single molecular behaviors using atomic force microscopy.Sensors (Switzerland),17(1),1-20.
MLA Li M,et al."Imaging and force recognition of single molecular behaviors using atomic force microscopy".Sensors (Switzerland) 17.1(2017):1-20.
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