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The dynamic interactions between chemotherapy drugs and plasmid DNA investigated by atomic force microscopy
其他题名基于AFM的化疗药物与质粒DNA间动态相互作用观测
Li M(李密); Liu LQ(刘连庆); Xiao XB(肖秀斌); Xi N(席宁); Wang YC(王越超)
作者部门机器人学研究室
关键词Afm Plasmid 化疗药物 Dna Methotrexate Arrows 甲氨蝶呤 Length 原子力显微镜 Purine
发表期刊Science China Materials
ISSN2095-8226
2017
卷号60期号:3页码:269-278
收录类别SCI ; EI ; CSCD
EI收录号20174804469089
WOS记录号WOS:000398129000008
CSCD记录号CSCD:5931839
产权排序1
摘要The advent of atomic force microscopy (AFM) provides a powerful tool for imaging individual DNA molecules. Chemotherapy drugs are often related to DNAs. Though many specific drug-DNA interactions have been observed by AFM, knowledge about the dynamic interactions between chemotherapy drugs and plasmid DNAs is still scarce. In this work, AFM was applied to investigate the nanoscale interactions between plasmid DNAs and two commercial chemotherapy drugs (methotrexate and cisplatin). Plasmid DNAs were immobilized on mica which was coated by silanes in advance. AFM imaging distinctly revealed the dynamic changes of single plasmid DNAs after the stimulation of methotrexate and cisplatin. Geometric features of plasmid DNAs were extracted from AFM images and the statistical results showed that the geometric features of plasmid DNAs changed significantly after the stimulation of drugs. This research provides a novel idea to study the actions of chemotherapy drugs against plasmid DNAs at the single-molecule level.
语种英语
WOS标题词Science & Technology ; Technology
WOS类目Materials Science, Multidisciplinary
关键词[WOS]SINGLE-MOLECULE ; CANCER-CELLS ; MEASUREMENTS REVEAL ; PERSISTENCE LENGTH ; MEMBRANE-PROTEINS ; SPECTROSCOPY ; CISPLATIN ; TEMPERATURE ; DEPENDENCE ; MORPHOLOGY
WOS研究方向Materials Science
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
被引频次:1[CSCD]   [CSCD记录]
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/20246
专题机器人学研究室
通讯作者Liu LQ(刘连庆); Xi N(席宁)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing, 100071, China
3.Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, 48824, United States
推荐引用方式
GB/T 7714
Li M,Liu LQ,Xiao XB,et al. The dynamic interactions between chemotherapy drugs and plasmid DNA investigated by atomic force microscopy[J]. Science China Materials,2017,60(3):269-278.
APA Li M,Liu LQ,Xiao XB,Xi N,&Wang YC.(2017).The dynamic interactions between chemotherapy drugs and plasmid DNA investigated by atomic force microscopy.Science China Materials,60(3),269-278.
MLA Li M,et al."The dynamic interactions between chemotherapy drugs and plasmid DNA investigated by atomic force microscopy".Science China Materials 60.3(2017):269-278.
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