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Dynamical modeling and analysis of viscoelastic properties of single cells
Wang B(王博); Wang WX(王文学); Wang YC(王越超); Liu B(刘斌); Liu LQ(刘连庆)
Department机器人学研究室
Source PublicationMicromachines
ISSN2072-666X
2017
Volume8Issue:6Pages:1-11
Indexed BySCI ; EI
EI Accession number20172403756163
WOS IDWOS:000404119100006
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China (Grant Nos. 61433017, 61673372, 61327014 and 61522312) and the CAS/SAFEA International Partnership Program for Creative Research Teams
KeywordDynamical Modeling Mechanical Properties Principal Component Analysis Atomic Force Microscopy Viscoelasticity
AbstractA single cell can be regarded as a complex network that contains thousands of overlapping signaling pathways. The traditional methods for describing the dynamics of this network are extremely complicated. The mechanical properties of a cell reflect the cytoskeletal structure and composition and are closely related to the cellular biological functions and physiological activities. Therefore, modeling the mechanical properties of single cells provides the basis for analyzing and controlling the cellular state. In this study, we developed a dynamical model with cellular viscoelasticity properties as the system parameters to describe the stress-relaxation phenomenon of a single cell indented by an atomic force microscope (AFM). The system order and parameters were identified and analyzed. Our results demonstrated that the parameters identified using this model represent the cellular mechanical elasticity and viscosity and can be used to classify cell types.
Language英语
WOS HeadingsScience & Technology ; Technology
WOS SubjectNanoscience & Nanotechnology ; Instruments & Instrumentation
WOS KeywordATOMIC-FORCE MICROSCOPY ; BREAST-CANCER ; NANOINDENTATION
WOS Research AreaScience & Technology - Other Topics ; Instruments & Instrumentation
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Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/20757
Collection机器人学研究室
Corresponding AuthorWang WX(王文学); Liu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.University of Chinese Academy of Sciences, Beijing 100049, China
Recommended Citation
GB/T 7714
Wang B,Wang WX,Wang YC,et al. Dynamical modeling and analysis of viscoelastic properties of single cells[J]. Micromachines,2017,8(6):1-11.
APA Wang B,Wang WX,Wang YC,Liu B,&Liu LQ.(2017).Dynamical modeling and analysis of viscoelastic properties of single cells.Micromachines,8(6),1-11.
MLA Wang B,et al."Dynamical modeling and analysis of viscoelastic properties of single cells".Micromachines 8.6(2017):1-11.
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