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Dynamical modeling and analysis of viscoelastic properties of single cells
Wang B(王博); Wang WX(王文学); Wang YC(王越超); Liu B(刘斌); Liu LQ(刘连庆)
作者部门机器人学研究室
关键词Dynamical Modeling Mechanical Properties Principal Component Analysis Atomic Force Microscopy Viscoelasticity
发表期刊Micromachines
ISSN2072-666X
2017
卷号8期号:6页码:1-11
收录类别SCI ; EI
EI收录号20172403756163
WOS记录号WOS:000404119100006
产权排序1
资助机构National Natural Science Foundation of China (Grant Nos. 61433017, 61673372, 61327014 and 61522312) and the CAS/SAFEA International Partnership Program for Creative Research Teams
摘要A single cell can be regarded as a complex network that contains thousands of overlapping signaling pathways. The traditional methods for describing the dynamics of this network are extremely complicated. The mechanical properties of a cell reflect the cytoskeletal structure and composition and are closely related to the cellular biological functions and physiological activities. Therefore, modeling the mechanical properties of single cells provides the basis for analyzing and controlling the cellular state. In this study, we developed a dynamical model with cellular viscoelasticity properties as the system parameters to describe the stress-relaxation phenomenon of a single cell indented by an atomic force microscope (AFM). The system order and parameters were identified and analyzed. Our results demonstrated that the parameters identified using this model represent the cellular mechanical elasticity and viscosity and can be used to classify cell types.
语种英语
WOS标题词Science & Technology ; Technology
WOS类目Nanoscience & Nanotechnology ; Instruments & Instrumentation
关键词[WOS]ATOMIC-FORCE MICROSCOPY ; BREAST-CANCER ; NANOINDENTATION
WOS研究方向Science & Technology - Other Topics ; Instruments & Instrumentation
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/20757
专题机器人学研究室
通讯作者Wang WX(王文学); Liu LQ(刘连庆)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.University of Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式
GB/T 7714
Wang B,Wang WX,Wang YC,et al. Dynamical modeling and analysis of viscoelastic properties of single cells[J]. Micromachines,2017,8(6):1-11.
APA Wang B,Wang WX,Wang YC,Liu B,&Liu LQ.(2017).Dynamical modeling and analysis of viscoelastic properties of single cells.Micromachines,8(6),1-11.
MLA Wang B,et al."Dynamical modeling and analysis of viscoelastic properties of single cells".Micromachines 8.6(2017):1-11.
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