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3D-printed peristaltic microfluidic systems fabricated from thermoplastic elastomer
Wang JY(王敬依); McMullen, Carlton; Yao P(姚萍); Jiao ND(焦念东); Kim, Min; Kim, Jin-Woo; Liu LQ(刘连庆); Tung, Steve
作者部门机器人学研究室
关键词Microfluidic System 3d Printing Insulin Detection
发表期刊Microfluidics and Nanofluidics
ISSN1613-4982
2017
卷号21期号:6页码:1-13
收录类别SCI ; EI
EI收录号20172403761583
WOS记录号WOS:000404213400005
产权排序1
资助机构National Natural Science Foundation of China (Grant No. 61573339) and the CAS FEA International Partnership Program for Creative Research Teams
摘要Recent advancements in 3D printing technology have provided a potential low-cost and time-saving alternative to conventional PDMS (polydimethylsiloxane)-based microfabrication for microfluidic systems. In addition to reducing the complexity of the fabrication procedure by eliminating such intermediate steps as molding and bonding, 3D printing also offers more flexibility in terms of structural design than the PDMS micromolding process. At present, 3D-printed microfluidic systems typically utilize a relatively ‘stiff’ printing material such as ABS (acrylonitrile butadiene styrene copolymers), which limits the implementation of large mechanical actuation for active pumping and mixing as routinely carried out in a PDMS system. In this paper, we report the development of an active 3D-printed microfluidic system with moving parts fabricated from a flexible thermoplastic elastomer (TPE). The 3D-printed microfluidic system consists of two pneumatically actuated micropumps and one micromixer. The completed system was successfully applied to the detection of low-level insulin concentration using a chemiluminescence immunoassay, and the test result compares favorably with a similarly designed PDMS microfluidic system. Prior to system fabrication and testing, the material properties of TPE were extensively evaluated. The result indicated that TPE is compatible with biological materials and its 3D-printed surface is hydrophilic as opposed to hydrophobic for a molded PDMS surface. The Young’s modulus of TPE is measured to be 16 MPa, which is approximately eight times higher than that of PDMS, but over one hundred times lower than that of ABS.
语种英语
WOS标题词Science & Technology ; Technology ; Physical Sciences
WOS类目Nanoscience & Nanotechnology ; Instruments & Instrumentation ; Physics, Fluids & Plasmas
关键词[WOS]DEVICES ; MICROPUMPS ; GLASS ; CHIP
WOS研究方向Science & Technology - Other Topics ; Instruments & Instrumentation ; Physics
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/20758
专题机器人学研究室
通讯作者Liu LQ(刘连庆); Tung, Steve
作者单位1.State Key Lab of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.University of Chinese Academy of Sciences, Beijing, China
3.Department of Mechanical Engineering, University of Arkansas, Fayetteville, AR, United States
4.Department of Physics, Williams College, Williamstown, MA, United States
5.Bio/Nano Technology Laboratory, Department of Biological and Agricultural Engineering, Institute for Nanoscience and Engineering, University of Arkansas, Fayetteville, AR, United States
推荐引用方式
GB/T 7714
Wang JY,McMullen, Carlton,Yao P,et al. 3D-printed peristaltic microfluidic systems fabricated from thermoplastic elastomer[J]. Microfluidics and Nanofluidics,2017,21(6):1-13.
APA Wang JY.,McMullen, Carlton.,Yao P.,Jiao ND.,Kim, Min.,...&Tung, Steve.(2017).3D-printed peristaltic microfluidic systems fabricated from thermoplastic elastomer.Microfluidics and Nanofluidics,21(6),1-13.
MLA Wang JY,et al."3D-printed peristaltic microfluidic systems fabricated from thermoplastic elastomer".Microfluidics and Nanofluidics 21.6(2017):1-13.
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