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A Bioinspired Alginate-Gum Arabic Hydrogel with Micro-/Nanoscale Structures for Controlled Drug Release in Chronic Wound Healing
Li M(李密); Li, Haichang; Li, Xiangguang; Zhu, Hua; Xu, Zihui; Liu LQ(刘连庆); Ma, Jianjie; Zhang, Mingjun
Department机器人学研究室
Source PublicationACS Applied Materials and Interfaces
ISSN1944-8244
2017
Volume9Issue:27Pages:22160-22175
Indexed BySCI ; EI
EI Accession number20172903955718
WOS IDWOS:000405764700011
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China (61503372, 61522312, U1613220, 61433017), the Youth Innovation Promotion Association CAS (2017243), and the CAS FEA International Partnership Program for Creative Research Teams
KeywordAlginate And Gum Arabic Atomic Force Microscopy (Afm) Bioinspired Hydrogel Drug Release And Delivery Recombinant Human Mg53 Protein (rhMg53) Wound Healing And Scarring
AbstractBiopolymeric hydrogels have drawn increasing research interest in biomaterials due to their tunable physical and chemical properties for both creating bioactive cellular microenvironment and serving as sustainable therapeutic reagents. Inspired by a naturally occurring hydrogel secreted from the carnivorous Sundew plant for trapping insects, here we have developed a bioinspired hydrogel to deliver mitsugumin 53 (MG53), an important protein in cell membrane repair, for chronic wound healing. Both chemical compositions and micro-/nanomorphological properties inherent from the natural Sundew hydrogel were mimicked using sodium alginate and gum arabic with calcium ion-mediated cross-linking. On the basis of atomic force microscopy (AFM) force measurements, an optimal sticky hydrogel scaffold was obtained through orthogonal experimental design. Imaging and mechanical analysis showed the distinct correlation between structural morphology, adhesion characteristics, and mechanical properties of the Sundew-inspired hydrogel. Combined characterization and biochemistry techniques were utilized to uncover the underlying molecular composition involved in the interactions between hydrogel and protein. In vitro drug release experiments confirmed that the Sundew-inspired hydrogel had a biphasic-kinetics release, which can facilitate both fast delivery of MG53 for improving the reepithelization process of the wounds and sustained release of the protein for treating chronic wounds. In vivo experiments showed that the Sundew-inspired hydrogel encapsulating with rhMG53 could facilitate dermal wound healing in mouse model. Together, these studies confirmed that the Sundew-inspired hydrogel has both tunable micro-/nanostructures and physicochemical properties, which enable it as a delivery vehicle for chronic wounding healing. The research may provide a new way to develop biocompatible and tunable biomaterials for sustainable drug release to meet the needs of biological activities.
Language英语
WOS HeadingsScience & Technology ; Technology
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS KeywordCELL-MEMBRANE REPAIR ; HUMAN MG53 PROTEIN ; BIOMEDICAL APPLICATIONS ; MECHANICAL-PROPERTIES ; ADHESION PROPERTIES ; CANCER-CELLS ; STEM-CELLS ; DELIVERY ; INJURY ; TISSUE
WOS Research AreaScience & Technology - Other Topics ; Materials Science
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/20806
Collection机器人学研究室
Corresponding AuthorLiu LQ(刘连庆); Ma, Jianjie; Zhang, Mingjun
Affiliation1.Department of Biomedical Engineering, College of Engineering, Ohio State University, Columbus, OH, 43210, United States
2.Dorothy M. Davis Heart and Lung Research Institute, Wexner Medical Center, Ohio State University, Columbus, OH, 43210, United States
3.Interdisciplinary Biophysics Graduate Program, Ohio State University, Columbus, OH, 43210, United States
4.Department of Surgery, Ohio State University, Columbus, OH, 43210, United States
5.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
6.College of Animal Science, South China Agricultural University, Guangzhou, 510642, China
Recommended Citation
GB/T 7714
Li M,Li, Haichang,Li, Xiangguang,et al. A Bioinspired Alginate-Gum Arabic Hydrogel with Micro-/Nanoscale Structures for Controlled Drug Release in Chronic Wound Healing[J]. ACS Applied Materials and Interfaces,2017,9(27):22160-22175.
APA Li M.,Li, Haichang.,Li, Xiangguang.,Zhu, Hua.,Xu, Zihui.,...&Zhang, Mingjun.(2017).A Bioinspired Alginate-Gum Arabic Hydrogel with Micro-/Nanoscale Structures for Controlled Drug Release in Chronic Wound Healing.ACS Applied Materials and Interfaces,9(27),22160-22175.
MLA Li M,et al."A Bioinspired Alginate-Gum Arabic Hydrogel with Micro-/Nanoscale Structures for Controlled Drug Release in Chronic Wound Healing".ACS Applied Materials and Interfaces 9.27(2017):22160-22175.
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