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Patterned microwell arrays for single-cell analysis & drug screening
Yang WG(杨文广); Yu HB(于海波); Wang YC(王越超); Liu LQ(刘连庆)
作者部门机器人学研究室
会议名称1st International Conference on Manipulation, Automation and Robotics at Small Scales, MARSS 2017
会议日期July 17-21, 2017
会议地点Montreal, Canada
会议录名称International Conference on Manipulation, Automation and Robotics at Small Scales, MARSS 2017 - Proceedings
出版者IEEE
出版地New York
2017
页码1-5
收录类别EI
EI收录号20174004233953
产权排序1
ISBN号978-1-5386-0346-8
关键词Micro-well Arrays Microfabrication Single-cell Drug Screening
摘要Nowadays, cells are commonly used for predicting whether the drug compounds will be effective and safe in human. The response of cell groups was usually analyzed, instead of single cell. However, individual cells within the same population even shows various characteristics. Understanding this heterogeneity is critical to studying how effective therapies will be in the clinic. Therefore, highly efficient analysis of single cell has become important for cellular biologists for both fundamental and drug screening. Recently, several methods including microscopy, laser capture microdissection, flow cytometry and microfluidic techniques have been developed for study the single cell. However, miniaturization, simplification and multifunction are still main challenges for the development of single cell analytical tool. In this paper, we have presented an easy-to-use and versatile method to fabricate various microwells for single cell analysis. Cells could grow into arbitrary shapes with constrained microwells. The microwells were able to be removed to investigate cell shapes effect on growth via our method. Furthermore, 3D multicellular spheroids which can be used for dug screening were formed based on micro-wells arrays.
语种英语
文献类型会议论文
条目标识符http://ir.sia.cn/handle/173321/21072
专题机器人学研究室
通讯作者Yu HB(于海波); Liu LQ(刘连庆)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China
2.University of Chinese Academy of Sciences, Beijing, 100049, China
推荐引用方式
GB/T 7714
Yang WG,Yu HB,Wang YC,et al. Patterned microwell arrays for single-cell analysis & drug screening[C]. New York:IEEE,2017:1-5.
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