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Atomic Force Microscopy in Characterizing Cell Mechanics for Biomedical Applications: A Review
Li M(李密); Dang D(党丹); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
Department机器人学研究室
Source PublicationIEEE TRANSACTIONS ON NANOBIOSCIENCE
ISSN1536-1241
2017
Volume16Issue:6Pages:523-540
Indexed BySCI ; EI
EI Accession number20174004223963
WOS IDWOS:000411682900014
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China [61503372, 61522312, U1613220, 61433017] ; Youth Innovation Promotion Association CAS [2017243] ; CAS FEA International Partnership Program for Creative Research Teams
KeywordAtomic Force Microscopy Cell Mechanics Young's Modulus Biomarker Stem Cell Cancer Cell
AbstractCell mechanics is a novel label-free biomarker for indicating cell states and pathological changes. The advent of atomic force microscopy (AFM) provides a powerful tool for quantifying the mechanical properties of single living cells in aqueous conditions. The wide use of AFM in characterizing cell mechanics in the past two decades has yielded remarkable novel insights in understanding the development and progression of certain diseases, such as cancer, showing the huge potential of cell mechanics for practical applications in the field of biomedicine. In this paper, we reviewed the utilization of AFM to characterize cell mechanics. First, the principle and method of AFM single-cell mechanical analysis was presented, along with the mechanical responses of cells to representative external stimuli measured by AFM. Next, the unique changes of cell mechanics in two types of physiological processes (stem cell differentiation, cancer metastasis) revealed by AFM were summarized. After that, the molecular mechanisms guiding cell mechanics were analyzed. Finally the challenges and future directions were discussed.
Language英语
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemical Research Methods ; Nanoscience & Nanotechnology
WOS KeywordPLURIPOTENT STEM-CELLS ; PROSTATE-CANCER CELLS ; POWER-LAW RHEOLOGY ; HIGH-SPEED AFM ; LIVING CELLS ; EXTRACELLULAR-MATRIX ; VISCOELASTIC PROPERTIES ; ELASTIC-MODULUS ; BREAST-CANCER ; MICROENVIRONMENTAL REGULATION
WOS Research AreaBiochemistry & Molecular Biology ; Science & Technology - Other Topics
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Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/21103
Collection机器人学研究室
Corresponding AuthorLi M(李密); Liu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.Department of Industrial and Manufacturing Systems Engineering, University of Hong Kong, Hong Kong
Recommended Citation
GB/T 7714
Li M,Dang D,Liu LQ,et al. Atomic Force Microscopy in Characterizing Cell Mechanics for Biomedical Applications: A Review[J]. IEEE TRANSACTIONS ON NANOBIOSCIENCE,2017,16(6):523-540.
APA Li M,Dang D,Liu LQ,Xi N,&Wang YC.(2017).Atomic Force Microscopy in Characterizing Cell Mechanics for Biomedical Applications: A Review.IEEE TRANSACTIONS ON NANOBIOSCIENCE,16(6),523-540.
MLA Li M,et al."Atomic Force Microscopy in Characterizing Cell Mechanics for Biomedical Applications: A Review".IEEE TRANSACTIONS ON NANOBIOSCIENCE 16.6(2017):523-540.
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