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Research on rat's pulmonary acute injury induced by lunar soil simulant
Sun Y(孙燕); Liu JG(刘金国); Zheng, Yongchun; Xiao, Chunling; Wan, Bing; Guo, Li; Wang, Xuguang; Bo, Wei
作者部门空间自动化技术研究室
关键词Acute Injury Lunar Soil Simulant Lung Rat
发表期刊Journal of the Chinese Medical Association
ISSN1726-4901
2018
卷号81期号:2页码:133-140
收录类别SCI
WOS记录号WOS:000425706600008
产权排序1
资助机构Science and Technology Research Fund of Shenyang Medical College ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Science Foundation of China ; Research Fund of China Manned Space Engineering ; Science and Technology Development Fund of Macau
摘要

Background: The steps to the moon never stopped after the Apollo Project. Lessons from manned landings on the moon have shown that lunar dust has great influence on the health of astronauts. In this paper, comparative studies between the lunar soil simulant (LSS) and PM2.5 were performed to discover their harm to human biological systems and explore the methods of prevention and treatment of dust poisoning for future lunar manned landings. Methods: Rats were randomly divided into the control group, two CAS-1 lunar soil simulant groups (tracheal perfusion with 7 mg and 0.7 mg, respectively, in a 1-mL volume) and the PM2.5 group (tracheal perfusion with 0.7 mg in a 1-mL volume). The biochemical indicators in the bronchoalveolar lavage fluid (BALF), MPO activity in the lung tissue, pathologic changes, and inflammatory cells in the BALF were measured after 4 h and 24 h. Results: The LSS group showed cytotoxicity that was closely related to the concentration. The figures of the two LSS groups (4 and 24 h) show that the alveolar septa were thickened. Additionally, it was observed that neutrophils had infiltrated, and various levels of inflammation occurred around the vascular and bronchial structures. Conclusion: The overall results of the acute effects of the lungs caused by dust showed that the lung toxicity of LSS was greater than that of PM2.5. LSS could induce lung damage and inflammatory lesions. The biomarkers in BALF caused by acute injury were consistent with histopathologic observations.

语种英语
WOS类目Medicine, General & Internal
关键词[WOS]BRONCHOALVEOLAR LAVAGE ; OXIDATIVE STRESS ; IN-VITRO ; ACTIVATION ; SURFACE ; MICE ; INFLAMMATION ; PARTICLES ; TOXICITY ; FUTURE
WOS研究方向General & Internal Medicine
资助项目Science and Technology Research Fund of Shenyang Medical College[20171020] ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department[20170520437] ; National Science Foundation of China[51775541] ; Research Fund of China Manned Space Engineering[030201] ; Science and Technology Development Fund of Macau[020/2014/A1]
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/21365
专题空间自动化技术研究室
通讯作者Sun Y(孙燕)
作者单位1.Shenyang Medical College, Shenyang, China
2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
3.National Astronomical Observatories, Chinese Academy of Sciences, Beijing, China
4.Laboratory Medicine of Central Hospital Affiliated to Shenyang Medical College, Shenyang, China
推荐引用方式
GB/T 7714
Sun Y,Liu JG,Zheng, Yongchun,et al. Research on rat's pulmonary acute injury induced by lunar soil simulant[J]. Journal of the Chinese Medical Association,2018,81(2):133-140.
APA Sun Y.,Liu JG.,Zheng, Yongchun.,Xiao, Chunling.,Wan, Bing.,...&Bo, Wei.(2018).Research on rat's pulmonary acute injury induced by lunar soil simulant.Journal of the Chinese Medical Association,81(2),133-140.
MLA Sun Y,et al."Research on rat's pulmonary acute injury induced by lunar soil simulant".Journal of the Chinese Medical Association 81.2(2018):133-140.
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