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Research on rat's pulmonary acute injury induced by lunar soil simulant
Sun Y(孙燕); Liu JG(刘金国); Zheng, Yongchun; Xiao, Chunling; Wan, Bing; Guo, Li; Wang, Xuguang; Bo, Wei
Department空间自动化技术研究室
Source PublicationJournal of the Chinese Medical Association
ISSN1726-4901
2018
Volume81Issue:2Pages:133-140
Indexed BySCI
WOS IDWOS:000425706600008
Contribution Rank1
Funding OrganizationScience and Technology Research Fund of Shenyang Medical College ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Science Foundation of China ; Research Fund of China Manned Space Engineering ; Science and Technology Development Fund of Macau
KeywordAcute Injury Lunar Soil Simulant Lung Rat
Abstract

Background: The steps to the moon never stopped after the Apollo Project. Lessons from manned landings on the moon have shown that lunar dust has great influence on the health of astronauts. In this paper, comparative studies between the lunar soil simulant (LSS) and PM2.5 were performed to discover their harm to human biological systems and explore the methods of prevention and treatment of dust poisoning for future lunar manned landings. Methods: Rats were randomly divided into the control group, two CAS-1 lunar soil simulant groups (tracheal perfusion with 7 mg and 0.7 mg, respectively, in a 1-mL volume) and the PM2.5 group (tracheal perfusion with 0.7 mg in a 1-mL volume). The biochemical indicators in the bronchoalveolar lavage fluid (BALF), MPO activity in the lung tissue, pathologic changes, and inflammatory cells in the BALF were measured after 4 h and 24 h. Results: The LSS group showed cytotoxicity that was closely related to the concentration. The figures of the two LSS groups (4 and 24 h) show that the alveolar septa were thickened. Additionally, it was observed that neutrophils had infiltrated, and various levels of inflammation occurred around the vascular and bronchial structures. Conclusion: The overall results of the acute effects of the lungs caused by dust showed that the lung toxicity of LSS was greater than that of PM2.5. LSS could induce lung damage and inflammatory lesions. The biomarkers in BALF caused by acute injury were consistent with histopathologic observations.

Language英语
WOS SubjectMedicine, General & Internal
WOS KeywordBRONCHOALVEOLAR LAVAGE ; OXIDATIVE STRESS ; IN-VITRO ; ACTIVATION ; SURFACE ; MICE ; INFLAMMATION ; PARTICLES ; TOXICITY ; FUTURE
WOS Research AreaGeneral & Internal Medicine
Funding ProjectScience and Technology Research Fund of Shenyang Medical College[20171020] ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department[20170520437] ; National Science Foundation of China[51775541] ; Research Fund of China Manned Space Engineering[030201] ; Science and Technology Development Fund of Macau[020/2014/A1]
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/21365
Collection空间自动化技术研究室
Corresponding AuthorSun Y(孙燕)
Affiliation1.Shenyang Medical College, Shenyang, China
2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
3.National Astronomical Observatories, Chinese Academy of Sciences, Beijing, China
4.Laboratory Medicine of Central Hospital Affiliated to Shenyang Medical College, Shenyang, China
Recommended Citation
GB/T 7714
Sun Y,Liu JG,Zheng, Yongchun,et al. Research on rat's pulmonary acute injury induced by lunar soil simulant[J]. Journal of the Chinese Medical Association,2018,81(2):133-140.
APA Sun Y.,Liu JG.,Zheng, Yongchun.,Xiao, Chunling.,Wan, Bing.,...&Bo, Wei.(2018).Research on rat's pulmonary acute injury induced by lunar soil simulant.Journal of the Chinese Medical Association,81(2),133-140.
MLA Sun Y,et al."Research on rat's pulmonary acute injury induced by lunar soil simulant".Journal of the Chinese Medical Association 81.2(2018):133-140.
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