SIA OpenIR  > 机器人学研究室
Dynamic Model for Characterizing Contractile Behaviors and Mechanical Properties of a Cardiomyocyte
Zhang C(张闯); Wang WX(王文学); He, Wenhui; Xi N(席宁); Wang YC(王越超); Liu LQ(刘连庆)
作者部门机器人学研究室
发表期刊BIOPHYSICAL JOURNAL
ISSN0006-3495
2018
卷号114期号:1页码:188-200
收录类别SCI
WOS记录号WOS:000419595500020
产权排序1
资助机构National Natural Science Foundation of China [61673372, 61433017, 61327014, 61522312] ; Chinese Academy of Sciences/State Administration of Foreign Experts Affairs (CAS/SAFEA) International Partnership Program for Creative Research Teams
摘要Studies on the contractile dynamics of heart cells have attracted broad attention for the development of both heart disease therapies and cardiomyocyte-actuated micro-robotics. In this study, a linear dynamic model of a single cardiomyocyte cell was proposed at the subcellular scale to characterize the contractile behaviors of heart cells, with system parameters representing the mechanical properties of the subcellular components of living cardiomyocytes. The system parameters of the dynamic model were identified with the cellular beating pattern measured by a scanning ion conductance microscope. The experiments were implemented with cardiomyocytes in one control group and two experimental groups with the drugs cytochalasin-D or nocodazole, to identify the system parameters of the model based on scanning ion conductance microscope measurements, measurement of the cellular Young's modulus with atomic force microscopy indentation, measurement of cellular contraction forces using the micro-pillar technique, and immunofluorescence staining and imaging of the cytoskeleton. The proposed mathematical model was both indirectly and qualitatively verified by the variation in cytoskeleton, beating amplitude, and contractility of cardiomyocytes among the control and the experimental groups, as well as directly and quantitatively validated by the simulation and the significant consistency of 90.5% in the comparison between the ratios of the Young's modulus and the equivalent comprehensive cellular elasticities of cells in the experimental groups to those in the control group. Apart from mechanical properties (mass, elasticity, and viscosity) of subcellular structures, other properties of cardiomyocytes have also been studied, such as the properties of the relative action potential pattern and cellular beating frequency. This work has potential implications for research on cytobiology, drug screening, mechanisms of the heart, and cardiomyocyte-based bio-syncretic robotics.
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/21499
专题机器人学研究室
通讯作者Wang WX(王文学); Liu LQ(刘连庆)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.University of Chinese Academy of Sciences, Beijing, China
3.Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
4.Emerging Technologies Institute, Department of Industrial and Manufacturing Systems Engineering, University of Hong Kong Pokfulam, Pokfulam, Hong Kong
推荐引用方式
GB/T 7714
Zhang C,Wang WX,He, Wenhui,et al. Dynamic Model for Characterizing Contractile Behaviors and Mechanical Properties of a Cardiomyocyte[J]. BIOPHYSICAL JOURNAL,2018,114(1):188-200.
APA Zhang C,Wang WX,He, Wenhui,Xi N,Wang YC,&Liu LQ.(2018).Dynamic Model for Characterizing Contractile Behaviors and Mechanical Properties of a Cardiomyocyte.BIOPHYSICAL JOURNAL,114(1),188-200.
MLA Zhang C,et al."Dynamic Model for Characterizing Contractile Behaviors and Mechanical Properties of a Cardiomyocyte".BIOPHYSICAL JOURNAL 114.1(2018):188-200.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Dynamic Model for Ch(2653KB)期刊论文作者接受稿开放获取ODC PDDL浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang C(张闯)]的文章
[Wang WX(王文学)]的文章
[He, Wenhui]的文章
百度学术
百度学术中相似的文章
[Zhang C(张闯)]的文章
[Wang WX(王文学)]的文章
[He, Wenhui]的文章
必应学术
必应学术中相似的文章
[Zhang C(张闯)]的文章
[Wang WX(王文学)]的文章
[He, Wenhui]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Dynamic Model for Characterizing Contractile Behaviors and Mechanical Properties of a Cardiomyocyte.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。