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题名:
Atomic force microscopy studies on cellular elastic and viscoelastic properties
作者: Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
作者部门: 机器人学研究室
通讯作者: Liu LQ(刘连庆) ; Xi N(席宁)
关键词: atomic force microscopy ; cell ; mechanical properties ; viscoelastic properties ; Young's modulus ; relaxation time
刊名: SCIENCE CHINA-LIFE SCIENCES
ISSN号: 1674-7305
出版日期: 2018
卷号: 61, 期号:1, 页码:57-67
收录类别: SCI
WOS记录号: WOS:000423730100007
产权排序: 1
项目资助者: National Natural Science Foundation of China [61503372, 61522312, U1613220, 61327014, 61433017] ; Youth Innovation Promotion Association CAS [2017243] ; CAS FEA International Partnership Program for Creative Research Teams
摘要: In this work, a method based on atomic force microscopy (AFM) approach-reside-retract experiments was established to simultaneously quantify the elastic and viscoelastic properties of single cells. First, the elastic and viscoelastic properties of normal breast cells and cancerous breast cells were measured, showing significant differences in Young's modulus and relaxation times between normal and cancerous breast cells. Remarkable differences in cellular topography between normal and cancerous breast cells were also revealed by AFM imaging. Next, the elastic and viscoelasitc properties of three other types of cell lines and primary normal B lymphocytes were measured; results demonstrated the potential of cellular viscoelastic properties in complementing cellular Young's modulus for discerning different states of cells. This research provides a novel way to quantify the mechanical properties of cells by AFM, which allows investigation of the biomechanical behaviors of single cells from multiple aspects.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sia.cn/handle/173321/21529
Appears in Collections:机器人学研究室_期刊论文

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作者单位: 1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.Department of Industrial and Manufacturing Systems Engineering, The University of Hong Kong, Hong Kong, China

Recommended Citation:
Li M,Liu LQ,Xi N,et al. Atomic force microscopy studies on cellular elastic and viscoelastic properties[J]. SCIENCE CHINA-LIFE SCIENCES,2018,61(1):57-67.
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