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Atomic force microscopy studies on cellular elastic and viscoelastic properties
Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
作者部门机器人学研究室
关键词Atomic Force Microscopy Cell Mechanical Properties Viscoelastic Properties Young's Modulus Relaxation Time
发表期刊SCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
2018
卷号61期号:1页码:57-67
收录类别SCI ; CSCD
WOS记录号WOS:000423730100007
CSCD记录号CSCD:6190092
产权排序1
资助机构National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; CAS FEA International Partnership Program for Creative Research Teams
摘要

In this work, a method based on atomic force microscopy (AFM) approach-reside-retract experiments was established to simultaneously quantify the elastic and viscoelastic properties of single cells. First, the elastic and viscoelastic properties of normal breast cells and cancerous breast cells were measured, showing significant differences in Young's modulus and relaxation times between normal and cancerous breast cells. Remarkable differences in cellular topography between normal and cancerous breast cells were also revealed by AFM imaging. Next, the elastic and viscoelasitc properties of three other types of cell lines and primary normal B lymphocytes were measured; results demonstrated the potential of cellular viscoelastic properties in complementing cellular Young's modulus for discerning different states of cells. This research provides a novel way to quantify the mechanical properties of cells by AFM, which allows investigation of the biomechanical behaviors of single cells from multiple aspects.

语种英语
WOS类目Biology
关键词[WOS]BREAST-CANCER CELLS ; LIVING CELLS ; MECHANICAL-PROPERTIES ; AFM INDENTATION ; TUMOR-CELLS ; SHAPE ; DISCRIMINATION ; LOCALIZATION ; FIBROBLASTS ; TEMPERATURE
WOS研究方向Life Sciences & Biomedicine - Other Topics
资助项目National Natural Science Foundation of China[61503372] ; National Natural Science Foundation of China[61522312] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[61327014] ; National Natural Science Foundation of China[61433017] ; Youth Innovation Promotion Association CAS[2017243] ; CAS FEA International Partnership Program for Creative Research Teams
引用统计
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/21529
专题机器人学研究室
通讯作者Liu LQ(刘连庆); Xi N(席宁)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.Department of Industrial and Manufacturing Systems Engineering, The University of Hong Kong, Hong Kong, China
推荐引用方式
GB/T 7714
Li M,Liu LQ,Xi N,et al. Atomic force microscopy studies on cellular elastic and viscoelastic properties[J]. SCIENCE CHINA-LIFE SCIENCES,2018,61(1):57-67.
APA Li M,Liu LQ,Xi N,&Wang YC.(2018).Atomic force microscopy studies on cellular elastic and viscoelastic properties.SCIENCE CHINA-LIFE SCIENCES,61(1),57-67.
MLA Li M,et al."Atomic force microscopy studies on cellular elastic and viscoelastic properties".SCIENCE CHINA-LIFE SCIENCES 61.1(2018):57-67.
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