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Atomic force microscopy studies on cellular elastic and viscoelastic properties
Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
Department机器人学研究室
Source PublicationSCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
2018
Volume61Issue:1Pages:57-67
Indexed BySCI ; CSCD
WOS IDWOS:000423730100007
CSCD IDCSCD:6190092
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; CAS FEA International Partnership Program for Creative Research Teams
KeywordAtomic Force Microscopy Cell Mechanical Properties Viscoelastic Properties Young's Modulus Relaxation Time
Abstract

In this work, a method based on atomic force microscopy (AFM) approach-reside-retract experiments was established to simultaneously quantify the elastic and viscoelastic properties of single cells. First, the elastic and viscoelastic properties of normal breast cells and cancerous breast cells were measured, showing significant differences in Young's modulus and relaxation times between normal and cancerous breast cells. Remarkable differences in cellular topography between normal and cancerous breast cells were also revealed by AFM imaging. Next, the elastic and viscoelasitc properties of three other types of cell lines and primary normal B lymphocytes were measured; results demonstrated the potential of cellular viscoelastic properties in complementing cellular Young's modulus for discerning different states of cells. This research provides a novel way to quantify the mechanical properties of cells by AFM, which allows investigation of the biomechanical behaviors of single cells from multiple aspects.

Language英语
WOS SubjectBiology
WOS KeywordBREAST-CANCER CELLS ; LIVING CELLS ; MECHANICAL-PROPERTIES ; AFM INDENTATION ; TUMOR-CELLS ; SHAPE ; DISCRIMINATION ; LOCALIZATION ; FIBROBLASTS ; TEMPERATURE
WOS Research AreaLife Sciences & Biomedicine - Other Topics
Funding ProjectNational Natural Science Foundation of China[61503372] ; National Natural Science Foundation of China[61522312] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[61327014] ; National Natural Science Foundation of China[61433017] ; Youth Innovation Promotion Association CAS[2017243] ; CAS FEA International Partnership Program for Creative Research Teams
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/21529
Collection机器人学研究室
Corresponding AuthorLiu LQ(刘连庆); Xi N(席宁)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
2.Department of Industrial and Manufacturing Systems Engineering, The University of Hong Kong, Hong Kong, China
Recommended Citation
GB/T 7714
Li M,Liu LQ,Xi N,et al. Atomic force microscopy studies on cellular elastic and viscoelastic properties[J]. SCIENCE CHINA-LIFE SCIENCES,2018,61(1):57-67.
APA Li M,Liu LQ,Xi N,&Wang YC.(2018).Atomic force microscopy studies on cellular elastic and viscoelastic properties.SCIENCE CHINA-LIFE SCIENCES,61(1),57-67.
MLA Li M,et al."Atomic force microscopy studies on cellular elastic and viscoelastic properties".SCIENCE CHINA-LIFE SCIENCES 61.1(2018):57-67.
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