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Modeling and analysis of living beating cardiomyocyte in sub-cell scale
Zhang C(张闯); Wang WX(王文学); Xi N(席宁); Wang YC(王越超); Liu LQ(刘连庆)
作者部门机器人学研究室
会议名称17th IEEE International Conference on Nanotechnology, NANO 2017
会议日期July 25-28, 2017
会议地点Pittsburgh, PA, United states
会议主办者IEEE Nanotechnology Council (NTC)
会议录名称2017 IEEE 17th International Conference on Nanotechnology, NANO 2017
出版者IEEE
出版地New York
2017
页码406-410
收录类别EI ; CPCI(ISTP)
EI收录号20180604700385
WOS记录号WOS:000434647500094
产权排序1
ISBN号978-1-5090-3028-6
摘要

The research on heart cells have attracted broad attention for the development of either heart disease therapy or muscle cell-based actuation for bio-syncretic robots. In order to study the mechanism and dynamics of beating activity of cardiomyocytes, many research methods have been proposed, such as the measurement of contractility and action potential of the cells. However, few of them has focused on the effect from the mechanical properties of sub-cell elements on the contraction performance of heart cells. In this work, a mechanical model of single heart cell was proposed based on the sub-cell structures, to study and control the contraction of the cardiomyocytes. The parameters of the parts in the theoretical model were identified with the cellular beating data obtained using Scanning Ion Conductance Microscopy (SICM) based on the derived mathematic model. Therefore, the contraction performance and the mechanical properties of sub-cell elements associated with the mechanical properties of parts in the model can be obtained for the further analysis of the relationship between the cell activity and sub-cell structures. This work is fundamental and meaningful for the research on cytobiology, heart mechanism and bio-syncretic robotics.

语种英语
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文献类型会议论文
条目标识符http://ir.sia.cn/handle/173321/21544
专题机器人学研究室
通讯作者Wang WX(王文学); Liu LQ(刘连庆)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.University of Chinese Academy of Sciences, Beijing 100049, China
3.Emerging Technologies Institute, Department of Industrial and Manufacturing Systems Engineering, University of Hong Kong, Pokfulam, Hong Kong
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GB/T 7714
Zhang C,Wang WX,Xi N,et al. Modeling and analysis of living beating cardiomyocyte in sub-cell scale[C]//IEEE Nanotechnology Council (NTC). New York:IEEE,2017:406-410.
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